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Related Experiment Video

Updated: Jan 20, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

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Pediatric malignancies: Is the prechemotherapy left ventricular function normal?

Jyothsna Akam-Venkata1, Gilda Kadiu1, James Galas1

  • 1Division of Cardiology, Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan, Detroit, Michigan.

Echocardiography (Mount Kisco, N.Y.)
|September 1, 2019
PubMed
Summary
This summary is machine-generated.

Pediatric cancer patients show reduced left ventricular (LV) systolic function before chemotherapy. This early LV dysfunction, measured by global longitudinal strain, is a novel finding requiring further investigation.

Keywords:
malignancypediatric echocardiographystrain

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Area of Science:

  • Cardiology
  • Pediatric Oncology
  • Echocardiography

Background:

  • Cardiotoxicity is a significant concern in pediatric cancer treatment.
  • Early detection of cardiac dysfunction is crucial for managing treatment outcomes.
  • Left ventricular (LV) systolic function can be affected by cancer itself, independent of treatment.

Purpose of the Study:

  • To compare LV systolic function in children with cancer before chemotherapy initiation with matched healthy controls.
  • To identify potential early cardiac changes using speckle tracking echocardiography.

Main Methods:

  • Retrospective analysis of echocardiograms from 89 pediatric cancer patients and 82 matched controls.
  • Utilized speckle tracking echocardiography to assess LV systolic function, including global longitudinal strain (GLS).
  • Compared LV ejection fraction, E/e' ratio, myocardial performance index, and shortening fraction between groups.

Main Results:

  • Cancer patients exhibited significantly lower LV longitudinal strain (LS) in apical and four-chamber views compared to controls.
  • Global longitudinal strain (GLS) was significantly reduced in pre-chemotherapy cancer patients.
  • Elevated E/e' ratio observed in cancer patients indicated diastolic dysfunction.
  • LV ejection fraction was lower in cancer patients, though within normal limits.
  • No significant differences were found in myocardial performance index or shortening fraction.

Conclusions:

  • Pediatric cancer patients demonstrate novel and unexplained abnormalities in LV GLS prior to chemotherapy.
  • These findings suggest potential pre-existing cardiac dysfunction in pediatric cancer patients.
  • Longitudinal studies are necessary to understand the implications of this early LV dysfunction.