Related Experiment Video

Updated: Jan 20, 2026

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
04:05

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy

Published on: August 22, 2025

721

Clinical outcomes of automated anastomotic devices: A metanalysis

Linda Renata Micali1, Francesco Matteucci1, Orlando Parise1

  • 1Cardiothoracic Department, Maastricht University Hospital, Maastricht, The Netherlands.

Journal of Cardiac Surgery
|September 1, 2019
PubMed

Insights

Automated proximal anastomotic devices (APADs) show good graft patency and low major adverse cardiovascular events (MACEs) after coronary artery bypass grafting (CABG). However, APADs do not appear to reduce neurological events or mortality.

Area of Science:

  • Cardiovascular Surgery
  • Medical Devices
  • Surgical Outcomes

Background:

  • Coronary artery bypass grafting (CABG) is a common procedure for severe coronary artery disease.
  • Automated proximal anastomotic devices (APADs) are used to create anastomoses during CABG.
  • Assessing the safety and efficacy of APADs is crucial for surgical practice.

Purpose of the Study:

  • To investigate neurological events, graft patency, major adverse cardiovascular events (MACEs), and mortality at 1 year post-CABG using APADs.
  • To compare the outcomes of APADs use with existing literature.
  • To evaluate the overall safety and effectiveness of APADs in CABG surgery.

Main Methods:

  • A systematic review of observational studies reporting APADs use in CABG was conducted.
  • Nine studies with a total of 718 patients were included.
  • Cumulative incidence and 95% confidence intervals were calculated to assess event rates.

Main Results:

  • The cumulative incidence of neurological complications was 4.8%.
  • Graft patency at 1 year was 90.5%.
  • The overall incidence of MACEs was 3.7%, and 1-year mortality was 5%.

Conclusions:

  • APADs are associated with satisfactory 1-year graft patency and a low incidence of MACEs.
  • APADs do not appear to reduce neurological events or mortality in CABG patients.
  • Further research is warranted to fully understand the long-term impact of APADs.
Abstract

Keywords:
coronary artery bypass graftingcoronary artery diseaseproximal anastomoses

More Related Videos

Automated Robotic Liquid Handling Assembly of Modular DNA Devices11:22

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

12.9K
Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy09:18

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

10.8K

Related Concept Videos

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy04:05

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy

Here, we present a protocol for endoscopic vacuum therapy (EVT) in the management of anastomotic leaks following total gastrectomy with...
721
Automated Robotic Liquid Handling Assembly of Modular DNA Devices11:22

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Here, an automated workflow to perform modular DNA "device" assembly using a modular cloning DNA assembly method on liquid-handling robots is presented. The protocol uses an intuitive software tool for generating liquid handler picklists for combinatorial DNA device library generation, which we demonstrate using two liquid handling...
12.9K
Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy09:18

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

The aim of this study is to present the most reliable clinical outcome measures and their correlations with quantitative muscle MRI in ambulant patients with Duchenne muscular...
10.8K
Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow09:03

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

Here, we present a protocol to harvest adherent cells from multi-layered flasks in a closed semi-automated manner using a counterflow centrifugation system. This protocol can be applied for harvesting both adherent and suspension cells from other cell expansion platforms with few modifications to the existing...
2.6K
Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System10:24

Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System

The goal of this protocol is to manufacture pathogen-specific clinical-grade T cells using a bench-top, automated, second generation cell enrichment device that incorporates a closed cytokine capture system and does not require dedicated staff or use of a GMP facility. The cytomegalovirus pp65-specific-T cells generated can be directly administered to...
12.8K
Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood08:58

Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood

This protocol demonstrates how to achieve femto molar detection sensitivity of proteins in 10 µL of whole blood within 30 min. This can be achieved by using electrospun nanofibrous mats integrated in a lab-on-a-disc, which offers high surface area as well as effective mixing and washing for enhanced signal-to-noise...
11.0K