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Trichomonal vaginitis refractory to treatment: case report
M S Sprott1, A M Kearns, R S Pattman
1Regional Public Health Laboratory, Newcastle upon Tyne.
Genitourinary Medicine
|December 1, 1988
Summary
This study details a seven-year treatment course for a woman with persistent vaginal trichomoniasis. Despite various therapies, including 5-nitroimidazoles and Lactobacillus acidophilus vaccination, the infection remained unresponsive.
Area of Science:
- Gynecology
- Infectious Diseases
- Microbiology
Background:
- Vaginal trichomoniasis is a common sexually transmitted infection caused by the protozoan parasite Trichomonas vaginalis.
- Treatment resistance can occur, posing challenges in clinical management and patient care.
Observation:
- A 25-year-old woman presented with symptomatic vaginal trichomoniasis requiring prolonged management.
- The patient underwent a seven-year treatment regimen encompassing multiple therapeutic modalities.
Findings:
- The patient received conventional and high-dose 5-nitroimidazoles, antimicrobials, acidifying agents, and a Lactobacillus acidophilus vaccine.
- Despite the comprehensive and extended treatment strategy, the vaginal trichomoniasis demonstrated persistent refractoriness to all interventions.
Implications:
- This case highlights the potential for treatment-refractory vaginal trichomoniasis, even with aggressive and varied therapeutic approaches.
- Further research into alternative treatment strategies and the mechanisms of resistance in Trichomonas vaginalis infections is warranted.