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Reduced spontaneous perspective taking in schizophrenia.

Lisa Kronbichler1, Renate Stelzig-Schöler2, Brandy-Gale Pearce2

  • 1Neuroscience Institute, Christian Doppler Medical Centre, Paracelsus Medical University, Ignaz-Harrer Straße 79, 5020 Salzburg, Austria; Centre for Cognitive Neuroscience, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria.

Psychiatry Research. Neuroimaging
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Schizophrenia (SZ) patients struggle with spontaneous visual perspective-taking, unlike healthy individuals. This suggests a core difference in how SZ patients process others' viewpoints, impacting social cognition.

Keywords:
FMRIImplicitPerspective takingSpontaneousVisual

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Area of Science:

  • Cognitive Neuroscience
  • Social Cognition
  • Psychiatry

Background:

  • Impaired visual perspective-taking is a known deficit in schizophrenia (SZ).
  • Previous research focused on how self-perspective affects other-perspective judgments.
  • The impact of others' perspectives on self-perspective processing in SZ remains underexplored.

Purpose of the Study:

  • To investigate spontaneous visual perspective-taking processes in individuals with schizophrenia (SZ).
  • To examine how inconsistent other-perspectives affect self-perspective judgments in SZ patients.
  • To explore neural correlates of perspective-taking using fMRI in SZ and healthy controls.

Main Methods:

  • fMRI experiment involving 24 healthy participants and 24 SZ patients.
  • Participants performed a visual perspective-taking task with social and non-social stimuli.
  • Stimulus visual perspectives were either consistent or inconsistent with the participant's self-perspective.

Main Results:

  • Healthy participants showed increased reaction times with inconsistent avatar perspectives, replicating prior findings.
  • Schizophrenia (SZ) patients did not exhibit this reaction time effect.
  • fMRI revealed similar occipital BOLD responses but group differences in the middle occipital gyrus.

Conclusions:

  • Schizophrenia (SZ) patients appear less likely to spontaneously compute others' visual perspectives.
  • This suggests a deficit in automatic social cognition and perspective-taking in SZ.
  • Neural differences in the middle occipital gyrus may underlie this altered perspective-taking ability.