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Updated: Jan 20, 2026

Assessing Immunological Synapse Topology through Live-Cell Imaging
Discovering the topology of complex networks via adaptive estimators
Daniel Alberto Burbano Lombana1, Randy A Freeman2, Kevin M Lynch3
1Department of Mechanical and Aerospace Engineering, New York University, Brooklyn, New York 11201, USA.
Abstract:
Behind any complex system in nature or engineering, there is an intricate network of interconnections that is often unknown. Using a control-theoretical approach, we study the problem of network reconstruction (NR): inferring both the network structure and the coupling weights based on measurements of each node's activity. We derive two new methods for NR, a low-complexity reduced-order estimator (which projects each node's dynamics to a one-dimensional space) and a full-order estimator for cases where a reduced-order estimator is not applicable. We prove their convergence to the correct network structure using Lyapunov-like theorems and persistency of excitation. Importantly, these estimators apply to systems with partial state measurements, a broad class of node dynamics and internode coupling functions, and in the case of the reduced-order estimator, node dynamics and internode coupling functions that are not fully known. The effectiveness of the estimators is illustrated using both numerical and experimental results on networks of chaotic oscillators.
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