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Updated: Jan 20, 2026

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
Published on: August 21, 2019
Resilience for stochastic systems interacting via a quasi-degenerate network
Sara Nicoletti1, Duccio Fanelli1, Niccolò Zagli2
1Dipartimento di Fisica e Astronomia, CSDC and INFN, Università degli Studi di Firenze, via G. Sansone 1, 50019 Sesto Fiorentino, Italy.
Abstract:
A stochastic reaction-diffusion model is studied on a networked support. In each patch of the network, two species are assumed to interact following a non-normal reaction scheme. When the interaction unit is replicated on a directed linear lattice, noise gets amplified via a self-consistent process, which we trace back to the degenerate spectrum of the embedding support. The same phenomenon holds when the system is bound to explore a quasidegenerate network. In this case, the eigenvalues of the Laplacian operator, which governs species diffusion, accumulate over a limited portion of the complex plane. The larger the network, the more pronounced the amplification. Beyond a critical network size, a system deemed deterministically stable, hence resilient, can develop seemingly regular patterns in the concentration amount. Non-normality and quasidegenerate networks may, therefore, amplify the inherent stochasticity and so contribute to altering the perception of resilience, as quantified via conventional deterministic methods.
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