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Updated: Jan 20, 2026

Transmembrane Domain Oligomerization Propensity determined by ToxR Assay
Published on: May 26, 2011
Determining velocity of detonation using high-resolution time domain reflectometry
1M-6, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, New Mexico 87545, USA.
Abstract:
Two methods are presented to make measurements of the length of a coaxial cable with submillimeter and submicrosecond accuracy. If the cable is destroyed by the passage of a strong shock, for instance, from the detonation of an explosive, a measure of the phase velocity of the detonation (VOD) can be obtained with high accuracy (≈0.25%). The first method introduces a series of short Gaussian electrical pulses (<300 ps) into the cable that reflect off the cable end and are compared to the time of the original outgoing pulse by using a fast digitizer (100 gigasamples per second). By curve fitting a Gaussian form to the outgoing and reflected pulses, a measurement of the cable length can be made with subsample accuracy. So, as long as the pulses do not overlap, a large number may be present in the cable at any time allowing pulse repetition rates of 40-135 MHz depending on the cable length. Averaging allows accurate VOD measurements to be made that are comparable with the best traditional techniques. The second method replaces the pulser with a wide-spectrum (0.1-10 GHz) amplified random noise source. A similar setup and digitizer are used before autocorrelating short (80-160 ns) subsamples of the total waveform to measure the reflected delay time. That is, a smaller amplitude version of the original waveform appears time shifted by twice the transit time in the cable and this time is estimated via autocorrelation. The advantage of this method is that a new subsample needs only to be selected from a time increment in which new spectral information is present for a new measure of the length to be made. In this manner, many more length estimates can be averaged to establish the VOD than with the Gaussian approach. A detailed description of the implementation of both methods is presented together with an example of the type of data collected and limitations found.
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