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Updated: Jan 20, 2026

Biolayer Interferometry Technology to Detect Interactions between Ligand and Analyte
Ultra-high-bandwidth polarization interferometry and optimal quadratic phase detection
1Physics Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, New Mexico 87545, USA.
Abstract:
A novel homodyne interferometer and analysis method are described which use orthogonal polarization components to measure large rapid changes in interferometric phase, in quadrature, in the presence of strong time-dependent attenuation of the scene beam. This approach overcomes the major sources of error associated with homodyne interferometry (sensitivity nulls, ambiguity in the direction of phase change when passing through a sensitivity null, and intolerance to beam power variations) while maintaining its intrinsic simplicity and speed, enabling extremely high-bandwidth, high-dynamic range measurements limited only by available detector technology. Using this technique, electron density in a magnetized plasma shock was measured with unprecedented bandwidth and resolution, revealing short-timescale features not previously observed.
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