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Amphiphilic polysaccharide based on curdlan: Synthesis and behaviour in aqueous solution.

I Popescu1, I M Pelin1, G L Ailiesei1

  • 1Petru Poni Institute of Macromolecular Chemistry, Aleea Grigore Ghica Voda 41A, 700487, Iasi, Romania.

Carbohydrate Polymers
|September 2, 2019
PubMed
Summary

A novel amphiphilic polyelectrolyte derived from curdlan, featuring quaternary ammonium groups, was synthesized. This new biomaterial exhibits promising antimicrobial properties against bacteria and fungi, suitable for biomaterial applications.

Keywords:
Amphiphilic polyelectrolyteAntimicrobial derivativeCationic curdlan derivativeQuaternary ammonium groups

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Organic Chemistry

Background:

  • Curdlan, a natural polysaccharide, serves as a versatile scaffold for developing functional biomaterials.
  • Polyelectrolytes with quaternary ammonium groups are known for their antimicrobial activities.
  • Developing novel antimicrobial agents is crucial for combating infectious diseases.

Purpose of the Study:

  • To synthesize and characterize a novel amphiphilic polyelectrolyte based on a curdlan derivative.
  • To investigate the hydrodynamic properties and self-aggregation behavior of the synthesized derivative.
  • To evaluate the antimicrobial efficacy of the new derivative against common bacterial and fungal pathogens.

Main Methods:

  • Synthesis of amphiphilic curdlan derivative with quaternary ammonium groups.
  • Structural characterization using FTIR, 1D and 2D NMR spectroscopy.
  • Hydrodynamic property analysis via capillary viscometry and intrinsic viscosity determination.
  • Self-aggregation studies using fluorescence spectroscopy and surface tension measurements.
  • Antibacterial and antifungal testing against E. coli, P. aeruginosa, and C. albicans.

Main Results:

  • Successful synthesis and comprehensive characterization of the amphiphilic curdlan derivative.
  • Determination of intrinsic viscosity and delimitation of concentration domains using scaling theory.
  • Evidence of self-aggregation behavior studied through fluorescence probes and surface tension.
  • Demonstrated significant antibacterial and antifungal activity.

Conclusions:

  • The synthesized amphiphilic curdlan derivative possesses desirable structural and hydrodynamic properties.
  • The derivative effectively self-aggregates, indicating potential for controlled release applications.
  • The observed antimicrobial activity suggests its utility as a standalone biopolymer or as a precursor for antimicrobial biomaterials.