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Updated: Jan 20, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
Published on: October 24, 2015
Evolving Surgical Options for Hepatocellular Carcinoma
Gregory C Wilson1, David A Geller1
1Department of Surgery, Liver Cancer Center, University of Pittsburgh Medical Center, 3471 Fifth Avenue, Suite 300, Pittsburgh, PA, USA.
Abstract:
Surgical resection and liver transplant remain the cornerstones of curative treatment options for hepatocellular carcinoma. Determining the best treatment option for each patient is a complex decision based on degree of liver cirrhosis, extent of tumor, and overall patient performance status. A multidisciplinary approach is best. With widespread adoption, the role of laparoscopic liver resection for hepatocellular carcinoma continues to expand. Long-term oncologic outcomes are similar for laparoscopic and open resection, with improved short-term results, mainly blood loss and hospital length of stay. Liver transplant remains the ideal treatment of cirrhotic patients with signs of portal hypertension and hepatocellular carcinoma.
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