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Related Experiment Video

Updated: Jan 20, 2026

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Differences in Biomarkers Pattern Between Severe Isolated Right and Left Ventricular Dysfunction After Cardiac

Jun Hyun Kim1, Caterina Cecilia Lerose2, Giovanni Landoni2

  • 1Department of Anesthesiology and Pain Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.

Journal of Cardiothoracic and Vascular Anesthesia
|September 2, 2019
PubMed
Summary
This summary is machine-generated.

Biomarker differences were found between patients with severe right ventricular (RV) dysfunction and severe left ventricular (LV) dysfunction after cardiac surgery. These findings may aid in understanding and managing post-cardiac surgery complications.

Keywords:
anesthesiabiomarkercardiac dysfunctioncardiopulmonary bypassintensive careleft ventricular failureliverright ventricular failureventricular dysfunction

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Area of Science:

  • Cardiology
  • Biomarkers
  • Cardiac Surgery

Background:

  • Severe isolated right ventricular (RV) or left ventricular (LV) dysfunction can occur after cardiac surgery with cardiopulmonary bypass.
  • Understanding the differences in biomarkers between these conditions is crucial for patient management.

Purpose of the Study:

  • To investigate potential differences in perioperative biomarkers between patients experiencing severe isolated RV dysfunction and those with severe isolated LV dysfunction following cardiac surgery.

Main Methods:

  • This observational study involved 46 patients who developed severe isolated RV or LV dysfunction after cardiac surgery.
  • Perioperative clinical and biomarker data were collected and analyzed.

Main Results:

  • Patients with severe RV dysfunction exhibited higher postoperative direct bilirubin, total bilirubin, glucose, and international normalized ratio (INR) compared to the LV dysfunction group.
  • The RV group also showed lower preoperative alanine transferase and higher INR at 4 and 48 hours post-surgery.
  • Mortality was observed in the RV dysfunction group, particularly in patients with preoperative atrial fibrillation undergoing double valve replacement.

Conclusions:

  • Significant differences in specific biomarkers exist between severe isolated RV and LV dysfunction post-cardiac surgery.
  • These biomarker variations may offer insights into the distinct pathophysiological processes and prognoses of RV versus LV dysfunction.