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Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
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Feed-forward loop between body composition, strength and performance in older adults.

Arindam RoyChoudhury1, Thuy-Tien L Dam2, Chenghuiyun Xu1

  • 1Division of Biostatistics and Epidemiology, Department of Healthcare Policy and Research, Weill Cornell Medicine, Cornell University, New York, NY, United States.

Mechanisms of Ageing and Development
|September 2, 2019
PubMed
Summary
This summary is machine-generated.

Frailty syndrome may stem from physiological feedback loops. This study reveals a feed-forward loop between body composition, strength, and physical performance in older adults, suggesting a cycle of decline.

Keywords:
Body compositionFrailtyGrip strengthPhysical activitySarcopenia

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Area of Science:

  • Gerontology
  • Physiology
  • Biomedical Science

Background:

  • Frailty syndrome is theorized to result from malfunctioning feedback mechanisms in interconnected physiological systems.
  • Empirical evidence supporting this hypothesis, particularly concerning feed-forward loops, is currently limited.

Purpose of the Study:

  • To investigate the presence of a feed-forward loop relationship among key components of the frailty syndrome.
  • To examine the interplay between body composition, muscle strength, and physical performance in the development of frailty.

Main Methods:

  • Statistical analysis of longitudinal data from 878 females and 588 males (aged 60-97) from the Rancho Bernardo Study.
  • Measurements included body composition (fat mass, lean mass via DXA scans), grip strength (dynamometer), and physical performance (time to walk a set distance).

Main Results:

  • Evidence of a feed-forward loop was identified between body composition, grip strength, and physical performance.
  • Adverse changes in body composition were found to negatively impact physical performance and grip strength.
  • These changes in performance and strength were also shown to further contribute to adverse body composition changes.

Conclusions:

  • The findings support the hypothesis that feed-forward loops exist between frailty components during its development.
  • Frailty may manifest as a consequence of dysregulated bioenergetics, driven by these cyclical physiological interactions.