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Updated: Jan 20, 2026

Source and Route of Pyrrolizidine Alkaloid Contamination in Tea Samples
Published on: September 28, 2022
Monoterpenoid indole alkaloids from the bark of Melodinus henryi
Juan He1, Fa-Lei Zhang1, Zheng-Hui Li1
1School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, Hubei 430074, China; National Demonstration Center for Experimental Ethnopharmacology Education (South-Central University for Nationalities), China.
Abstract:
Four new alkaloids, melodinines W1-W4 (1-4), together with twenty one known alkaloids (5-25) were isolated from Melodinus henryi. The structures with absolute configurations were elucidated by extensive MS and NMR spectroscopic methods, as well as the single crystal X-ray diffraction and ECD calculations. All compounds were evaluated for their cytotoxicities to five human cancer cell lines. Many compounds showed certain cytotoxicities to five human cancer cell lines with an IC50 range of 1.4-29.4 μM.
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