Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System12:19

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System

27.5K
Transcranial magnetic stimulation (TMS) is a non-invasive tool to gain insight on the physiology and function of the human nervous system. Here, we present our TMS techniques to study cortical excitability of the upper limb and lumbar...
27.5K
Multifunctional Setup for Studying Human Motor Control Using Transcranial Magnetic Stimulation, Electromyography, Motion Capture, and Virtual Reality08:09

Multifunctional Setup for Studying Human Motor Control Using Transcranial Magnetic Stimulation, Electromyography, Motion Capture, and Virtual Reality

11.5K
Transcranial magnetic stimulation, electromyography, and 3D motion capture are commonly used non-invasive techniques for investigating neuromuscular function in humans. In this paper, we describe a protocol that synchronously samples data generated by all three of these tools along with the unique addition of virtual reality stimulus presentation and...
11.5K
Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation10:11

Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation

11.8K
When administering transcranial direct current stimulation (tDCS), reproducible electrode preparation and placement are vital for a tolerated and effective session. The purpose of this article is to demonstrate updated modern setup procedures for the administration of tDCS and related transcranial electrical stimulation techniques, such as transcranial alternating current stimulation...
11.8K
Transcranial Direct Current Stimulation (tDCS) for Memory Enhancement10:37

Transcranial Direct Current Stimulation (tDCS) for Memory Enhancement

15.6K
A protocol for memory enhancement by using transcranial direct current stimulation (tDCS) targeting dorsolateral prefrontal and posterior parietal cortices, as core cortical nodes within hippocampo-cortical network, is presented. The protocol has been well evaluated in healthy-participant studies and is applicable to aging and dementia research as well.
15.6K
Transcranial Direct Current Stimulation (tDCS) of Wernicke's and Broca's Areas in Studies of Language Learning and Word Acquisition12:49

Transcranial Direct Current Stimulation (tDCS) of Wernicke's and Broca's Areas in Studies of Language Learning and Word Acquisition

17.9K
Here, we describe a protocol for using transcranial direct current stimulation for psycho- and neurolinguistic experiments aimed at studying, in a naturalistic yet fully controlled way, the role of cortical areas of the human brain in word learning, and a comprehensive set of behavioral procedures for assessing the...
17.9K
Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation11:11

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation

9.6K
Transcranial Alternating Current Stimulation (tACS) allows the modulation of cortical excitability in a frequency-specific fashion. Here we show a unique approach which combines online tACS with single pulse Transcranial Magnetic Stimulation (TMS) in order to "probe" cortical excitability by means of Motor Evoked Potentials.
9.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex differences in plasma endocannabinoids and related lipids before and after single and repeated mTBI: an exploratory study of endolipid plasma biomarkers.

Frontiers in molecular neuroscience·2026
Same author

Mescaline Alters Cerebellar Function, Global Connectivity, and Frequency-Selective Acoustic Gating: A BOLD fMRI Study in Awake Rats.

Neuroscience bulletin·2026
Same author

Functional and microstructural biomarkers of repetitive mild head injury in a conscious momentum exchange mouse model.

Journal of neuroscience methods·2026
Same author

Complexity of resting cortical activity predicts neurophysiological responses to theta-burst stimulation but fails to generalize: A rigorous machine-learning approach.

PLoS computational biology·2026
Same author

Anodal high-definition transcranial direct current stimulation reveals a specific role for posterior parietal cortex in interlimb generalization.

Cerebral cortex (New York, N.Y. : 1991)·2026
Same author

Beyond the toad's kiss: Mapping acute 5-MeO-DMT effects on brain connectivity across sex and dose using awake rat neuroimaging.

Neuropharmacology·2026

Related Experiment Video

Updated: Jan 20, 2026

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System
12:19

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System

Published on: January 20, 2012

27.5K

Prospects for transcranial temporal interference stimulation in humans: A computational study.

Sumientra Rampersad1, Biel Roig-Solvas1, Mathew Yarossi2

  • 1Department of Electrical and Computer Engineering, Northeastern University, Boston, USA.

Neuroimage
|September 2, 2019
PubMed
Summary
This summary is machine-generated.

Transcranial temporal interference stimulation (tTIS) shows promise for deeper, more focused brain stimulation than tACS. Simulations in human models suggest tTIS offers better steerability and focality, though peak field strengths are lower than in mice.

Keywords:
Bioelectricity simulationFinite element modeling (FEM)Non-invasive brain stimulationOptimizationTemporal interferenceTranscranial alternating current stimulation (tACS)

More Related Videos

Multifunctional Setup for Studying Human Motor Control Using Transcranial Magnetic Stimulation, Electromyography, Motion Capture, and Virtual Reality
08:09

Multifunctional Setup for Studying Human Motor Control Using Transcranial Magnetic Stimulation, Electromyography, Motion Capture, and Virtual Reality

Published on: September 3, 2015

11.5K
Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation
10:11

Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation

Published on: January 3, 2020

11.8K

Related Experiment Videos

Last Updated: Jan 20, 2026

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System
12:19

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System

Published on: January 20, 2012

27.5K
Multifunctional Setup for Studying Human Motor Control Using Transcranial Magnetic Stimulation, Electromyography, Motion Capture, and Virtual Reality
08:09

Multifunctional Setup for Studying Human Motor Control Using Transcranial Magnetic Stimulation, Electromyography, Motion Capture, and Virtual Reality

Published on: September 3, 2015

11.5K
Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation
10:11

Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation

Published on: January 3, 2020

11.8K

Area of Science:

  • Neuroscience
  • Biophysics
  • Computational modeling

Background:

  • Transcranial alternating current stimulation (tACS) modulates superficial brain activity.
  • Transcranial temporal interference stimulation (tTIS) uses two high-frequency fields for deeper, steerable brain modulation.
  • Previous studies showed promising tTIS results in mice.

Purpose of the Study:

  • To understand electric fields generated by tTIS.
  • To evaluate tTIS potential in humans via simulations.
  • To optimize tTIS parameters for targeted stimulation.

Main Methods:

  • Simulated tTIS in murine and human head models.
  • Used finite element modeling to analyze electric fields.
  • Systematically varied electrode configurations and input currents.
  • Performed an exhaustive search of 146 million current patterns across 88 electrode locations.

Main Results:

  • Validated tTIS efficacy in mice, reaching suprathreshold stimulation (up to 383 V/m).
  • Demonstrated steerability of the peak tTIS field by manipulating input field strengths.
  • Human models showed deep brain stimulation comparable to tACS but with less superficial activity.
  • Identified optimal four-electrode patterns for targeting pallidum, hippocampus, and motor cortex.

Conclusions:

  • tTIS offers enhanced focality and steerability compared to tACS.
  • While peak human field strengths were lower than in mice, tTIS shows potential for precise deep brain stimulation.
  • Optimized tTIS configurations can effectively target specific brain regions.