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Updated: Jan 20, 2026

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Published on: June 9, 2023
Caffeine not associated with irritable behaviour in very low-birth-weight infants
Tomoki Maeda1, Kazuhito Sekiguchi1, Rieko Wasada1
1Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan.
Abstract:
This paper is an examination of irritable behaviour in very low-birth-weight infants in relation to caffeine or aminophylline. We assessed tremulous movement (a sub-score of General Movements Optimality Score) in 18 caffeine-treated subjects and 18 aminophylline-treated subjects. Caffeine, unlike aminophylline, was not associated with irritable behaviour at standard dose.
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