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Sleep disorders and cognitive dysfunction in acromegaly.

A Wennberg1, R Lorusso2, F Dassie3

  • 1Department of Neuroscience, University of Padua, Padova, PD, Italy.

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|September 2, 2019
PubMed
Summary
This summary is machine-generated.

Poor sleep quality in acromegaly patients is linked to reduced quality of life and cognitive function. Addressing sleep disturbances may improve overall well-being in this population.

Keywords:
AcromegalyCognitionGrowth hormoneQuality of lifeSleep

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Area of Science:

  • Endocrinology
  • Neurology
  • Sleep Medicine

Background:

  • Sleep disorders are prevalent in acromegaly, potentially exacerbating cognitive impairment.
  • Acromegaly treatment and comorbidities may further increase cognitive risks.

Purpose of the Study:

  • To investigate the association between sleep disturbances and cognitive dysfunction in acromegaly patients.

Main Methods:

  • 67 acromegaly patients underwent neurocognitive assessment.
  • Validated questionnaires (AcroQoL, Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index) were used.

Main Results:

  • Poor sleep quality correlated with lower global cognitive z-scores.
  • Daytime somnolence was linked to reduced physical quality of life.
  • Sleep quality significantly impacted all aspects of Acromegaly Quality of Life (AcroQoL).

Conclusions:

  • Poor sleep quality is robustly associated with diminished quality of life in acromegaly.
  • Evidence suggests a link between poor sleep and cognitive impairment in acromegaly patients.