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[Takayasu's arteritis and atherosclerosis].

A Hatri¹, R Guermaz², J-P Laroche³

¹Unité de médecine vasculaire, clinique d'Elbiar, Alger, Algérie.

Journal De Medecine Vasculaire

|September 3, 2019

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Takayasu's arteritis and rheumatoid arthritis patients exhibit accelerated atherosclerosis, even with low cardiovascular risk. Inflammation plays a key role, necessitating proactive cardiovascular prevention strategies for Takayasu's disease.

Area of Science:

Cardiovascular Medicine
Rheumatology
Vascular Biology

Background:

Chronic inflammatory diseases like SLE and RA increase cardiovascular morbidity and mortality due to premature atherosclerosis.
Atherosclerosis is linked to chronic systemic inflammation, independent of traditional cardiovascular risk factors.
Large artery vasculitis, such as Takayasu's disease, involves both systemic and local vascular inflammation.

Purpose of the Study:

To investigate the prevalence and characteristics of atherosclerosis in patients with Takayasu's arteritis compared to rheumatoid arthritis and controls.
To assess the role of inflammation in the development of premature atherosclerosis in these patient groups.

Main Methods:

A prospective case-control study involving 64 Takayasu's arteritis patients, 50 RA patients, and a control group.

Keywords:

Athérosclérose Maladie de Takayasu Takayasu's disease atherosclerosis

Related Experiment Videos

Assessment of classic cardiovascular risk factors and calculation of risk using the Framingham equation.

Measurement of carotid intima-media thickness (IMT) and evaluation for carotid, aortic, and femoral atheroma.

Main Results:

No significant difference in calculated cardiovascular risk was observed between Takayasu's, RA, and control groups.
Subclinical atherosclerosis (IMT > 0.70mm and/or atheroma plaque) was significantly higher in Takayasu's patients (87%) and RA patients (76%) compared to controls (48%).
Carotid IMT was significantly higher in Takayasu's patients (0.91mm) compared to RA patients (0.76mm) and controls (0.71mm).

Conclusions:

Atherosclerosis in Takayasu's disease is accelerated and premature, occurring in younger individuals with low cardiovascular risk.
Systemic and local inflammation in Takayasu's arteritis likely drives accelerated atherosclerosis.
An active cardiovascular prevention strategy is recommended for patients with Takayasu's disease.