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Related Experiment Video

Updated: Jan 20, 2026

Wind Tunnel Experiments to Study Chaparral Crown Fires

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Published on: November 14, 2017

Firing Up Cold Tumors.

Wan-Chen Cheng¹, Ping-Chih Ho¹

¹Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Cancer Research, University of Lausanne, Epalinges, Switzerland.

Trends in Cancer

|September 3, 2019

Summary

This summary is machine-generated.

Understanding tumor-intrinsic pathways that control T cell infiltration is key for improving immune checkpoint blockade therapy. This review discusses how these pathways shape the tumor immune microenvironment and potential reprogramming strategies.

Keywords:

antitumor immune cycle conventional type I dendritic cells immune checkpoint blockade resistance tumor microenvironment

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Last Updated: Jan 20, 2026

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Published on: March 20, 2014

Area of Science:

Oncology
Immunology
Cancer Biology

Background:

Tumor-intrinsic pathways significantly influence the tumor immune microenvironment.
T cell infiltration is critical for the efficacy of immune checkpoint blockade (ICB) therapy.
Understanding these regulatory mechanisms is essential for advancing cancer treatment.

Purpose of the Study:

To review recent advancements in understanding tumor-intrinsic pathways that regulate T cell infiltration.
To discuss how these pathways orchestrate the tumor immune status.
To explore potential interventions for reprogramming the tumor microenvironment.

Main Methods:

Literature review of recent research on tumor-intrinsic pathways and T cell infiltration.
Analysis of studies investigating immune cell orchestration within tumors.
Synthesis of findings on therapeutic strategies for tumor microenvironment modulation.

Main Results:

Tumor-intrinsic signaling pathways actively shape the immune landscape within the tumor.
Specific pathways dictate the extent and type of T cell infiltration.
Reprogramming these pathways holds promise for enhancing anti-tumor immunity.

Conclusions:

Elucidating tumor-intrinsic regulation of T cell infiltration is vital for optimizing ICB therapy.
Targeting these pathways offers a promising strategy for cancer treatment.
Further research into reprogramming the tumor microenvironment is warranted.