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Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
Published on: October 31, 2010
Bone Quality Measured Using Calcaneal Quantitative Ultrasonography Is Reduced Among Children with HIV in
Stephen M Arpadi1, Cara B Thurman2, Faeezah Patel3
1Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY.
Insights
Children with human immunodeficiency virus (HIV) show poorer bone quality, including increased porosity and reduced strength. This bone deficit persists over time, potentially raising fracture risks in affected children.
Area of Science:
- Pediatrics
- Bone Health
- Infectious Diseases
Background:
- Human immunodeficiency virus (HIV) infection is associated with various health complications.
- Bone health is a critical aspect of overall well-being in children.
- Understanding the long-term effects of HIV on bone development is essential.
Purpose of the Study:
- To evaluate bone quality in South African children with HIV.
- To track changes in bone quality over a two-year period.
- To compare bone quality in children with and without HIV.
Main Methods:
- Quantitative ultrasound (QUS) was used to assess bone quality.
- The study followed a cohort of South African children over two years.
- Bone quality parameters were compared between children with HIV and control groups.
Main Results:
- Children with HIV demonstrated persistently lower bone quality compared to controls.
- Findings indicate increased bone porosity in children with HIV.
- Reduced bone strength was observed in the HIV-positive group.
Conclusions:
- Children with HIV exhibit compromised bone quality.
- The observed bone deficits suggest a potentially elevated risk of fractures.
- Longitudinal monitoring of bone health is crucial for children living with HIV.
Abstract:
We evaluated bone quality among South African children with HIV over a 2-year period by quantitative ultrasound (QUS). Children with HIV have persistently lower bone quality compared with controls reflecting increased porosity, reduced strength, and possibly an increased short- and long-term risk of fracture.
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