Mortality study in patients at weaning from mechanical ventilation

To explain mortality in the ICU and in hospital among patients subjected to invasive mechanical ventilation.

A prospective, 9-month observational cohort study was carried out.

A Department of Intensive Care Medicine.

Consecutive patients requiring invasive mechanical ventilation were followed-up on until hospital discharge or death.

None.

Date of admission, day of first spontaneous breathing test, length of mechanical ventilation, final extubation date, days in ICU, days in hospital or discharge from ICU, SAPS-3 score, WIND study classification, day of death, hospital discharge.

There were 266 patients: 40 in group 0 of the WIND classification (15%; 95% CI 11-20%); 166 in group 1 (62%; 95% CI 56-68%); 38 in group 2 (14%; 95% CI 11-19%); and 22 in group 3 (8%; 95% CI 6-12%. Logistic regression analysis showed group 3 to have the highest hospital mortality (group 3 vs. group 1; odds ratio 4.0; 95% CI 1.5-10.8; P=.007). However, Cox regression analysis showed no significant differences (hazard ratio group 3 vs. group 1, 1.6; 95% CI 0.7-3.4; P=ns).

In our study, considering exposure time, the probability of mortality was the same among the 3 different groups of patients with at least one spontaneous breathing test.