Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

4.0K
Here, we present a protocol for renal sympathetic denervation (RDN) in mice with hypertension induced by Angiotensin II infusion. The procedure is repeatable, convenient and allows to study the regulatory mechanisms of RDN on hypertension and cardiac...
4.0K
One-step Protocol for Evaluation of the Mode of Radiation-induced Clonogenic Cell Death by Fluorescence Microscopy06:47

One-step Protocol for Evaluation of the Mode of Radiation-induced Clonogenic Cell Death by Fluorescence Microscopy

11.9K
Research on ionizing radiation (IR)-induced clonogenic cell death is important for understanding the effects of IR on malignant tumors and normal tissues. Here, we describe a one-step assay for assessing the major modes of IR-induced clonogenic cell death based on morphology of 4',6-diamidino-2-phenylindole dihydrochloride (DAPI)-stained nuclei visualized by fluorescence...
11.9K
Biological Effects of Radiation02:59

Biological Effects of Radiation

17.7K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
17.7K
Acupuncture Treatment in a Mouse Model of Chronic Hypoxia-Induced Cognitive Dysfunction03:26

Acupuncture Treatment in a Mouse Model of Chronic Hypoxia-Induced Cognitive Dysfunction

1.8K
Here, we describe a protocol for implementing mild anesthesia and acupuncture treatment on a chronic hypoxia mouse model and conducting behavioral tests to assess the cognitive alterations post-treatment.
1.8K
Abdominal Massage to Improve Motor Dysfunction in Rats with Cerebral Palsy08:24

Abdominal Massage to Improve Motor Dysfunction in Rats with Cerebral Palsy

2.6K
Here, we present a set of massage manipulations in the rat model of cerebral palsy that can considerably improve the motor function of cerebral palsy...
2.6K
Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

15.9K
Radiation therapy is a highly complex cancer treatment that requires multiple specialists to create a treatment plan and provide quality assurance (QA) prior to delivery to a patient. This protocol describes the use of a fully automated system, the Radiation Planning Assistant (RPA), to create high-quality radiation treatment...
15.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing Clinical Decision Support for Antibiotic Prescribing in Pediatric Acute Respiratory Tract Infections: A Usability Study.

Applied clinical informatics·2026
Same author

Toward accessible mRNA LNP formulation: systematic evaluation of mixing strategies and key parameters.

Scientific reports·2026
Same author

Identification and toxicity prediction of metribuzin transformation products in activated sludge using suspect and nontarget screening.

Ecotoxicology and environmental safety·2026
Same author

Preoperative Left Ventricular Ejection Fraction is Associated With Delayed Extubation After Surgical Correction of Neuromuscular Scoliosis.

Journal of pediatric orthopedics·2026
Same author

A temporal keyword co-occurrence network mining framework for detecting structural transitions in cancer biomarker research (2006-2023).

Scientific reports·2026
Same author

Beyond seeking information: Lessons learned from a qualitative investigation of the information practices of parents about COVID-19 vaccination in Canada.

Human vaccines & immunotherapeutics·2026
Same journal

HER2-mutated lung squamous cell carcinoma responding to trastuzumab deruxtecan followed by pyrotinib: a Case Report.

Frontiers in pharmacology·2026
Same journal

Awareness, attitudes, and self-reported clinical management of antimicrobial-associated neurocognitive adverse effects among healthcare providers in Saudi Arabia.

Frontiers in pharmacology·2026
Same journal

Low-dose dasatinib in second-line therapy or beyond for the treatment of chronic-phase chronic myeloid leukemia: a real-world cohort study.

Frontiers in pharmacology·2026
Same journal

Natural products reshape osteosarcoma cell fate: promoting cell death.

Frontiers in pharmacology·2026
Same journal

<i>Leonurus japonicus</i> Houtt. extract containing isoquercitrin reduces airway inflammation in mice with allergic asthma.

Frontiers in pharmacology·2026
Same journal

Enhancing diabetes treatment by targeted nucleic acid and drug delivery using cell-penetrating peptides, peptide nucleic acids, and receptor targeting.

Frontiers in pharmacology·2026
See all related articles

Related Experiment Video

Updated: Jan 20, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

4.0K

Baicalein Mitigates Radiation-Induced Enteritis by Improving Endothelial Dysfunction.

Hyosun Jang1, Janet Lee1, Sunhoo Park1,2

  • 1Laboratory of Radiation Exposure & Therapeutics, National Radiation Emergency Medical Center, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea.

Frontiers in Pharmacology
|September 3, 2019
PubMed
Summary
This summary is machine-generated.

Baicalein, a natural flavonoid, effectively treats radiation-induced intestinal inflammation by protecting endothelial cells and improving gut barrier function. This study highlights baicalein

Keywords:
adherent moleculesbaicaleinendothelial cellsintestinal inflammationirradiation

More Related Videos

One-step Protocol for Evaluation of the Mode of Radiation-induced Clonogenic Cell Death by Fluorescence Microscopy
06:47

One-step Protocol for Evaluation of the Mode of Radiation-induced Clonogenic Cell Death by Fluorescence Microscopy

Published on: October 23, 2017

11.9K
Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research
03:26

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research

Published on: December 8, 2023

1.8K

Related Experiment Videos

Last Updated: Jan 20, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

4.0K
One-step Protocol for Evaluation of the Mode of Radiation-induced Clonogenic Cell Death by Fluorescence Microscopy
06:47

One-step Protocol for Evaluation of the Mode of Radiation-induced Clonogenic Cell Death by Fluorescence Microscopy

Published on: October 23, 2017

11.9K
Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research
03:26

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research

Published on: December 8, 2023

1.8K

Area of Science:

  • Gastroenterology and Hepatology
  • Oncology
  • Pharmacology

Background:

  • Radiation therapy for abdominal cancers and nuclear accidents can cause intestinal injury, modeled as radiation-induced enteritis.
  • Endothelial dysfunction is a key factor in radiation enteritis, promoting inflammation and disease progression.
  • Baicalein, a flavonoid from Scutellaria baicalensis, possesses known anti-inflammatory and antioxidant properties.

Purpose of the Study:

  • To investigate the therapeutic potential of baicalein in mitigating endothelial dysfunction associated with radiation-induced intestinal inflammation.
  • To evaluate baicalein's effects on histological damage, intestinal permeability, and inflammatory markers in a mouse model of radiation enteritis.

Main Methods:

  • Histological analysis, bacterial translocation, and intestinal permeability assays were conducted in a radiation-induced enteritis mouse model.
  • Leukocyte infiltration and inflammatory cytokine expression were assessed.
  • Endothelial-derived adhesion molecules were analyzed in human umbilical vein endothelial cells (HUVECs) and irradiated intestinal tissue to evaluate baicalein's effect on endothelial dysfunction.

Main Results:

  • Radiation exposure caused significant intestinal damage, including villi shortening and impaired crypt function.
  • Baicalein treatment attenuated histological damage and improved intestinal barrier function.
  • Baicalein inhibited radiation-induced adhesion molecule expression in HUVECs and intestinal tissue, reducing leukocyte infiltration and mitigating inflammation.

Conclusions:

  • Baicalein accelerates crypt regeneration by promoting endothelial recovery following radiation damage.
  • Baicalein demonstrates therapeutic efficacy against radiation-induced intestinal inflammation through the attenuation of endothelial damage.