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The Myth of the Placebo Response
Wayne B Jonas1,2,3
1Samueli Integrative Health Programs, Alexandria, VA, United States.
The "placebo response" is a myth. It is not a biological reaction to inert substances but rather reflects the inherent healing capacity influenced by context, which should be termed the "meaning response" or "healing response."
Area of Science:
- Medical research
- Clinical trials
- Philosophy of medicine
Background:
- The concept of a "placebo response" is widely accepted in medicine.
- This concept is based on flawed assumptions about reductionistic science and specific effects in healing.
- The term "placebo response" causes confusion among patients, clinicians, regulators, and scientists.
Purpose of the Study:
- To challenge the existence and utility of the term "placebo response."
- To propose alternative terminology that better reflects the mechanisms of healing.
- To advocate for a paradigm shift in understanding and enhancing healing.
Main Methods:
- Conceptual analysis of the term "placebo response."
- Critique of current methodologies in clinical trials that rely on placebo controls.
- Argumentation for a new framework for understanding healing.
Main Results:
- The "placebo response" is biologically impossible when defined as a response to an inert substance.
- Healing is an inherent capacity influenced by psychological, social, and contextual factors.
- Current pharmaceutical industry practices and regulatory standards are built on a flawed premise.
Conclusions:
- The term "placebo response" should be abandoned.
- The phenomenon should be understood as the "meaning response" or "healing response."
- Adopting this new terminology will accelerate the understanding and enhancement of healing.
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