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Related Experiment Videos

Recipient selection for heart-lung transplantation.

A L Harjula1, J C Baldwin, P E Oyer

  • 1Department of Cardiovascular Surgery, Stanford University Medical Center, CA.

Scandinavian Journal of Thoracic and Cardiovascular Surgery
|January 1, 1988
PubMed
Summary

Heart-lung transplantation is an evolving therapy for severe heart and lung disease. Careful patient selection and improved techniques have led to excellent survival rates, though donor availability remains a challenge.

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Area of Science:

  • Cardiology
  • Thoracic Surgery
  • Transplantation Medicine

Background:

  • Cardiac transplantation is a standard therapy for end-stage heart failure.
  • Heart-lung transplantation remains an experimental therapy for end-stage heart and lung disease.
  • Significant advancements have been made since the clinical application of heart-lung transplantation began in March 1981.

Purpose of the Study:

  • To evaluate the clinical experience and outcomes of heart-lung transplantation.
  • To identify suitable candidates for heart-lung transplantation.
  • To discuss future directions and limitations in heart-lung transplantation.

Main Methods:

  • Review of 6-year clinical experience with heart-lung transplantation.
  • Analysis of donor care, surgical techniques, post-operative management, and rejection treatment.

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  • Evaluation of patient selection criteria, including physiological status and co-morbidities.

    • Main Results:

    • Patients with Eisenmenger's physiology and primary pulmonary hypertension are suitable candidates.
    • Excellent operative survival (100%) achieved in the last ten heart-lung transplantations.
    • Donor availability is the primary limiting factor for the number of future heart-lung transplantations.

    Conclusions:

    • Heart-lung transplantation shows promising results with careful patient selection and optimized management.
    • Future recipient populations may expand to include pediatric patients and those with cystic fibrosis.
    • Continued improvements in donor and recipient selection, along with organ preservation, are crucial for advancing heart-lung transplantation.