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Updated: Jan 20, 2026

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CXCR4-Directed Imaging in Solid Tumors.

Rudolf A Werner1,2,3, Stefan Kircher4, Takahiro Higuchi1,2,5

  • 1Department of Nuclear Medicine, University of Wuerzburg, Wuerzburg, Germany.

Frontiers in Oncology
|September 3, 2019
PubMed
Summary
This summary is machine-generated.

CXCR4-targeted imaging with [68Ga]Pentixafor-PET/CT showed moderate expression in most newly diagnosed solid tumors. This suggests CXCR4-directed imaging may have limited utility in managing these cancers.

Keywords:
CXCR4[68Ga]Pentixaforchemokine receptorsolid tumorstheranostics

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiochemistry

Background:

  • While CXCR4-targeted diagnostics and endoradiotherapy are established for hematologic diseases, their application in solid tumors is less explored.
  • CXCR4 (C-X-C motif chemokine receptor 4) is a target of interest for theranostic applications in oncology.

Purpose of the Study:

  • To evaluate the feasibility of CXCR4-targeted imaging using [68Ga]Pentixafor-PET/CT in various newly diagnosed, treatment-naïve solid tumors.
  • To assess the correlation between [68Ga]Pentixafor uptake and histological CXCR4 expression.

Main Methods:

  • Nineteen patients with diverse solid tumors underwent [68Ga]Pentixafor-PET/CT scans.
  • Tumor uptake was assessed visually and semi-quantitatively (SUVmax, TBR), compared with immunohistochemistry and [18F]FDG PET/CT.

Main Results:

  • 52.6% of primary tumors were visually detectable with moderate uptake (median SUVmax 5.4, median TBR 2.6).
  • A good correlation was observed between [68Ga]Pentixafor uptake and histological CXCR4 expression (R=0.62, P<0.05).
  • [68Ga]Pentixafor showed lower uptake compared to [18F]FDG PET/CT in the limited number of patients assessed.

Conclusions:

  • CXCR4 expression detected by [68Ga]Pentixafor-PET/CT and immunohistochemistry was moderate in this cohort of solid tumors.
  • CXCR4-directed imaging may not be a primary tool for managing the majority of solid tumors.