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Related Concept Videos

Hypertension I: Introduction01:28

Hypertension I: Introduction

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Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
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Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

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Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
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Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

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The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
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Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

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The presentation of detailed methods for the evaluation of right ventricle function will enhance the quality and reliability of pulmonary hypertension research, offering a robust framework for future studies and enhancing reproducibility across different...
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Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

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Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
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Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

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Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
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Articles linked to this work by shared authors, journal, and citation graph.

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Effect of angiotensin-converting enzyme blockade, alone or combined with blockade of soluble epoxide hydrolase, on the course of congestive heart failure and occurrence of renal dysfunction in Ren-2 transgenic hypertensive rats with aorto-caval fistula.

Physiological research·2018
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Epoxyeicosatrienoic Acids and 20-Hydroxyeicosatetraenoic Acid on Endothelial and Vascular Function.

Advances in pharmacology (San Diego, Calif.)·2016
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WX-III-287-19 A Possible Thromboxane Antagonist in Bovine Coronary Arteries.

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Inhibition of soluble epoxide hydrolase does not improve the course of congestive heart failure and the development of renal dysfunction in rats with volume overload induced by aorto-caval fistula.

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Related Experiment Video

Updated: Jan 20, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

737

Epoxyeicosanoids in hypertension.

J D Imig1

  • 1Department of Pharmacology and Toxicology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, USA. jdimig@mcw.edu.

Physiological Research
|September 3, 2019
PubMed
Summary

Increasing epoxyeicosatrienoic acids (EETs) can lower blood pressure and combat cardiovascular disease. Targeting soluble epoxide hydrolase (sEH) offers a promising therapeutic strategy for hypertension.

Area of Science:

  • Cardiovascular Science
  • Renal Physiology
  • Pharmacology

Background:

  • Epoxyeicosatrienoic acids (EETs), or epoxyeicosanoids, exert significant renal and cardiovascular effects.
  • Soluble epoxide hydrolase (sEH) regulates EET levels by degrading and inactivating them.
  • Animal and human studies indicate EETs' potential to lower blood pressure and mitigate renal and cardiovascular disease.

Purpose of the Study:

  • To evaluate the therapeutic potential of increasing EET levels for hypertension management.
  • To explore the role of sEH in regulating EETs' beneficial actions.

Main Methods:

  • Review of extensive animal hypertension studies.
  • Analysis of human studies investigating EET levels in hypertension.
  • Examination of pharmacological and genetic approaches to elevate epoxyeicosanoids.

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Last Updated: Jan 20, 2026

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Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

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Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension
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Main Results:

  • EETs demonstrate vascular, epithelial transport, and anti-inflammatory actions that reduce blood pressure.
  • Increased EET levels are associated with improved endothelial vascular function and sodium excretion.
  • Elevated epoxyeicosanoids help oppose hypertension and related renal and cardiovascular complications.

Conclusions:

  • Increasing epoxyeicosanoids, through sEH inhibitors or EET analogs, represents a promising therapeutic strategy for hypertension.
  • Modulating EET levels offers a novel approach to managing hypertension and its associated cardiovascular and renal sequelae.