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Related Experiment Video

Updated: Jan 20, 2026

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
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Circadian variability in airways characteristics: A spirometric study.

Manish Goyal1, Arun Goel2, Sandeep Bhattacharya3

  • 1Department of Physiology, All India Institute of Medical Sciences , Bhubaneswar , Odisha , India.

Chronobiology International
|September 3, 2019
PubMed
Summary
This summary is machine-generated.

This study found that lung function in healthy young men varies significantly throughout the day, with different patterns suggesting distinct chronophenotypes. This may explain conditions like nocturnal asthma.

Keywords:
COPDDiurnalFEV1PEFasthmanocturnal

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Area of Science:

  • Pulmonary Medicine
  • Chronobiology
  • Respiratory Physiology

Background:

  • Asthma and COPD patients experience symptom exacerbation during night and early morning.
  • Previous studies on airway caliber variability used peak expiratory flow rate, primarily reflecting large airways.
  • This study investigates circadian variability in smaller airways using Forced Expiratory Volume in the First Second (FEV1) and Mid Expiratory Flow rate.

Purpose of the Study:

  • To investigate the circadian variability of airway caliber in healthy young adults.
  • To analyze diurnal patterns of spirometric parameters including FEV1 and Mid Expiratory Flow rate.
  • To identify potential chronophenotypes of respiratory function.

Main Methods:

  • Recruited 104 healthy male volunteers (18-26 years) with similar daily routines.
  • Performed spirometry at 7 time points throughout a 24-hour period (5:00 to 23:00 h).
  • Analyzed data for diurnal variability and fitted Cosinor curves to determine circadian rhythm characteristics (MESOR, Amplitude, Acrophase).

Main Results:

  • Significant differences in spirometric parameters were observed across different times of the day.
  • Lung function parameters generally followed a sinusoidal pattern, with lowest values at night and highest during the day.
  • Circadian rhythm for FEV1 was significant in 31% of subjects, with acrophase distribution indicating interindividual chronophenotypes.

Conclusions:

  • The study identified different chronophenotypes in healthy individuals, suggesting nocturnal asthma might represent a distinct phenotype.
  • Findings highlight the dynamic interplay of airway geometry and neuro-chemical influences on respiratory function.
  • Portable spirometers and home monitoring may be crucial for identifying chronophenotypes and personalizing chronotherapeutic interventions.