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Updated: Jan 20, 2026
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
Could circRNA be a new biomarker for pre-eclampsia?
Rana Shafabakhsh1, Naghmeh Mirhosseini2, Shala Chaichian3,4
1Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
Insights
Pre-eclampsia, a pregnancy complication, poses risks to mothers and fetuses. Circular RNAs (circRNAs) show promise as early detection biomarkers for pre-eclampsia, though research is ongoing.
Area of Science:
- Obstetrics and Gynecology
- Molecular Biology
- Genetics
Background:
- Pre-eclampsia is a major cause of maternal and fetal mortality and morbidity.
- Current risk factors identify only 30% of susceptible pregnancies.
- Early detection biomarkers are crucial due to pre-eclampsia's heterogeneous nature.
Purpose of the Study:
- To review current evidence on circular RNAs (circRNAs) in pre-eclampsia.
- To explore the potential of circRNAs as biomarkers for pre-eclampsia.
- To assess the mechanisms underlying circRNA involvement in pre-eclampsia.
Main Methods:
- Literature review of recent studies on circRNAs and pre-eclampsia.
- Analysis of circRNA characteristics (abundance, specificity, organization).
- Assessment of proposed molecular mechanisms.
Main Results:
- Circular RNAs (circRNAs) exhibit unique properties making them suitable biomarkers.
- Emerging evidence suggests circRNAs play a role in pre-eclampsia pathogenesis.
- Further research is needed to validate circRNAs as reliable pre-eclampsia biomarkers.
Conclusions:
- Circular RNAs (circRNAs) represent a promising area for pre-eclampsia biomarker discovery.
- Understanding circRNA mechanisms could lead to improved early detection strategies.
- Increased awareness among clinicians regarding circRNAs is warranted.
Abstract:
Pre-eclampsia is a devastating complication of pregnancy which is characterized by hypertension and proteinuria in pregnant women. Pre-eclampsia is important as it is the leading cause of death. Moreover, untreated pre-eclampsia might lead to other lethal complications, for both fetus and mother. Pre-eclampsia can also affect the quality of life in affected women. Despite a large number of risk factors for pre-eclampsia, these risk factors are able to detect just 30% of women who are susceptible to pre-eclampsia. Heterogeneous manifestations of pre-eclampsia necessitate the discovery of potential biomarkers required for its early detection. Circular RNAs (circRNAs) are a type of RNA which are more abundant, specific, and highly organized compared with other types of RNA. Accordingly, circRNAs have been suggested as one of the potential biomarkers for different diseases. Recently, researchers have shown interest in the effects of circRNAs in pre-eclampsia, although the current evidence is limited. The majority of obstetricians are probably not aware of circRNAs as a useful biomarker. Here, we aimed to summarize recent supporting evidence and assess the mechanisms by which circRNAs are involved in pre-eclampsia.
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