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Related Concept Videos

Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
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Oral Bacterial Infection and Shedding in Drosophila melanogaster09:32

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This protocol describes methods to orally expose and infect the fruit fly Drosophila melanogaster with bacterial pathogens, and to measure the number of infectious bacteria shed following gut infection. We further describe the effect of immune mutants on fly survival following oral bacterial...
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Stages of Infection01:26

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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis07:59

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This manuscript describes the use of a bioluminescent strain of African trypanosomes to enable the tracking of late stage infection and demonstrates how in vivo live imaging can be used to visualize infections within the central nervous system in...
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Use of Galleria mellonella as a Model Organism to Study Legionella pneumophila Infection

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The larva of the wax moth Galleria mellonella was recently established as an in vivo model to study Legionella pneumophila infection. Here, we demonstrate fundamental techniques to characterize the pathogenesis of Legionella in the larvae, including inoculation, measurement of bacterial virulence and replication as well as extraction and analysis of infected...
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Related Experiment Video

Updated: Jan 20, 2026

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection
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Prophylaxis of mould infections.

E Moreno-García, M Chumbita, P Puerta-Alcalde

  • 1Carolina Garcia-Vidal, Infectious Diseases Department, Hospital Clínic de Barcelona-IDIBAPS, Universitat de Barcelona, Barcelona, Spain. carolgv75@hotmail.com.

Revista Espanola De Quimioterapia : Publicacion Oficial De La Sociedad Espanola De Quimioterapia
|September 3, 2019
PubMed
Summary
This summary is machine-generated.

Antifungal prophylaxis significantly improves survival in patients with hematological conditions. However, evolving immunosuppressive treatments necessitate continuous updates in antifungal strategies to combat rising invasive fungal infection risks.

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Area of Science:

  • Hematology
  • Infectious Diseases
  • Pharmacology

Background:

  • Invasive fungal infections (IFIs) are a major cause of death in hematological patients.
  • Antifungal prophylaxis has dramatically improved survival rates in this vulnerable population.
  • Newer antifungals offer improved efficacy and reduced toxicity compared to older agents.

Purpose of the Study:

  • To review the current landscape of antifungal prophylaxis in hematological patients.
  • To highlight the challenges posed by emerging immunosuppressive therapies.
  • To emphasize the need for ongoing adaptation of antifungal strategies.

Main Methods:

  • Literature review of recent studies on antifungal prophylaxis.
  • Analysis of trends in immunosuppressive treatments and IFI incidence.
  • Synthesis of data on newer antifungal agents.

Main Results:

  • Antifungal prophylaxis remains critical for survival in hematological patients.
  • Increasing use of novel immunosuppressants expands the population at risk for IFIs.
  • Development of more effective and safer antifungal drugs is ongoing.

Conclusions:

  • Despite advances, invasive fungal infections remain a significant threat in hematology.
  • The dynamic nature of immunosuppressive therapies requires continuous reassessment of prophylaxis protocols.
  • Regular updates in antifungal strategies are essential to manage evolving risks and improve patient outcomes.