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Related Concept Videos

miRNA Expression Analyses in Prostate Cancer Clinical Tissues11:29

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Intra-prostatic Injection of Cancer Cells: A Technique to Deliver Cancer Cells for Establishing Orthotopic Prostate Cancer Mouse Model05:07

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Modeling Prostate Cancer in Genetically-engineered Mouse Models: A CRISPR/Cas9-mediated Localized Gene Editing Technique in Mouse Anterior Prostate Lobe Cells04:40

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Updated: Jan 20, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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Hypofractionation for clinically localized prostate cancer.

Brigid E Hickey1, Melissa L James, Tiffany Daly

  • 1Radiation Oncology Mater Service, Princess Alexandra Hospital, 31 Raymond Terrace, Brisbane, Queensland, Australia, 4101.

The Cochrane Database of Systematic Reviews
|September 3, 2019
PubMed
Summary
This summary is machine-generated.

Hypofractionated radiation therapy (fewer, larger doses) shows similar cancer outcomes and toxicity compared to conventional radiation for localized prostate cancer. This approach offers potential convenience and resource benefits without compromising patient results.

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Area of Science:

  • Radiation Oncology
  • Urologic Oncology
  • Clinical Trials

Background:

  • Hypofractionation (fewer, larger radiation doses) is explored for localized prostate cancer to enhance convenience and resource utilization.
  • Feasibility requires hypofractionation to be as effective as conventional fractionation regarding cancer outcomes, toxicity, and quality of life.

Purpose of the Study:

  • To compare the efficacy and safety of hypofractionated external beam radiation therapy (EBRT) versus conventionally fractionated EBRT for localized prostate cancer.

Main Methods:

  • Systematic review and meta-analysis of randomized controlled trials comparing hypofractionated and conventionally fractionated EBRT for prostate cancer.
  • Searches included major databases (CENTRAL, MEDLINE, Embase) up to March 2019, with no language or publication status limitations.
  • Standard Cochrane methodology was employed for data extraction, quality assessment, and analysis using Review Manager 5.

Main Results:

  • Hypofractionation demonstrated comparable prostate cancer-specific survival (low-certainty evidence) and overall survival (high-certainty evidence) versus conventional fractionation.
  • No significant difference was observed in metastasis-free survival (low-certainty evidence) or biochemical recurrence-free survival (moderate-certainty evidence).
  • Moderate-certainty evidence suggests little to no difference in late genitourinary (GU) toxicity and acute GU toxicity, with uncertain effects on late gastrointestinal (GI) toxicity.

Conclusions:

  • Moderate hypofractionation (up to 3.4 Gy/fraction) yields similar oncologic outcomes (disease-specific, metastasis-free, overall survival) for prostate cancer.
  • The study indicates little to no increase in acute or late toxicity with hypofractionation compared to conventional fractionation.
  • Hypofractionated EBRT appears to be a viable alternative for localized prostate cancer treatment, offering comparable efficacy and safety.