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The human pancreatic stone protein.

A De Caro1, L Multigner, J C Dagorn

  • 1Unité de Recherches de Pathologie Digestive, INSERM U31, Marseille, France.

Biochimie
|September 1, 1988
PubMed
Summary

Pancreatic stone protein (PSP) stabilizes calcium carbonate in pancreatic juice, preventing stone formation. Lower PSP levels are linked to chronic calcifying pancreatitis, suggesting its role in disease prevention.

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Area of Science:

  • Biochemistry
  • Gastroenterology
  • Molecular Biology

Background:

  • Chronic calcifying pancreatitis (CCP) involves pancreatic duct stones, primarily calcium carbonate (CaCO3).
  • An organic matrix, mainly pancreatic stone protein (PSP), is associated with these stones.
  • PSP exists in various secreted forms (PSP S2-5) synthesized in pancreatic acinar cells.

Purpose of the Study:

  • To investigate the role of pancreatic stone protein (PSP) in preventing calcium carbonate (CaCO3) precipitation in pancreatic juice.
  • To determine if PSP concentration is altered in patients with chronic calcifying pancreatitis (CCP).

Main Methods:

  • Analysis of pancreatic juice composition and protein forms.
  • In vitro studies on CaCO3 nucleation and crystal growth inhibition by PSP S.
  • Comparison of PSP S levels in CCP patients versus healthy controls.

Main Results:

  • Pancreatic juice is supersaturated with CaCO3, indicating a need for stabilizers.
  • PSP S exhibits in vitro activity inhibiting CaCO3 nucleation and growth.
  • PSP S concentration was significantly lower in pancreatic juice from CCP patients compared to controls.

Conclusions:

  • Pancreatic stone protein (PSP) likely acts as a stabilizer preventing CaCO3 precipitation in pancreatic juice.
  • Reduced PSP S levels may contribute to the pathogenesis of chronic calcifying pancreatitis (CCP).
  • PSP S represents a new family of pancreatic secretory proteins crucial for maintaining pancreatic juice stability.

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