Both "canonical" and "immunological" preeclampsia subtypes demonstrate changes in placental immune cell composition

Katherine Leavey¹, David Grynspan², Brian J Cox³

¹Department of Physiology, University of Toronto, Ontario, Canada.

|September 4, 2019

Abstract:

Our prior work investigating the heterogeneity of preeclampsia identified multiple placental subtypes of this disorder, including a "canonical" group with maternal vascular malperfusion and an "immunological" group with signs of allograft rejection. Here, we perform a pilot immunohistochemistry study to investigate if an increase in infiltrating maternal immune cells is contributing to the "immunological" pathology subtype. This revealed an enrichment of monocytes and/or neutrophils (CD68 ⁺ and MPO⁺ cells) in the intervillous space of these placentas. Surprisingly, "canonical" samples also demonstrated a significant result, with decreased CD68 staining. As such, further immunohistochemistry to assess immune contributions in preeclampsia subtypes is warranted.

Keywords:

Immune cells Immunohistochemistry Placenta Preeclampsia Subtypes

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Abstract:

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