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Related Experiment Video

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Insights into neonatal thrombosis.

Gili Kenet1, Omri Cohen1, Tido Bajorat2

  • 1National Hemophilia Center, Institute of Thrombosis and Hemostasis and the Amalia Biron Research Institute, Sheba Medical Center, Tel-Hashomer, Israel; Sackler School of Medicine, Tel Aviv University, Israel.

Thrombosis Research
|September 4, 2019
PubMed
Summary

Neonatal thrombosis is increasingly recognized due to better diagnostics and survival. This review covers developmental hemostasis, thrombosis pathogenesis, and risk factors like thrombophilia in newborns, focusing on perinatal arterial ischemic stroke.

Keywords:
AnticoagulantNeonatesThrombosis\Developmental hemostasis

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Area of Science:

  • Neonatal Medicine
  • Hematology
  • Pediatric Thrombosis

Background:

  • Neonatal thrombosis awareness is rising with improved diagnostics and survival rates.
  • Developmental hemostasis presents unique physiological differences compared to adults.
  • Sick preterm neonates are particularly vulnerable to thrombotic events.

Purpose of the Study:

  • To review the concept and manifestations of developmental hemostasis in neonatal thrombosis.
  • To explore the pathogenesis of thrombosis in neonates, focusing on perinatal arterial ischemic stroke (PAS).
  • To discuss the role of thrombophilia and present a meta-analysis of risk factors for PAS.

Main Methods:

  • Literature review on neonatal thrombosis and developmental hemostasis.
  • Analysis of hemostatic protein concentrations and coagulation inhibitors in neonates.
  • Meta-analysis of studies on thrombophilic risk factors for perinatal arterial ischemic stroke.

Main Results:

  • Neonatal hemostasis is characterized by age-related physiological differences.
  • Increased von Willebrand factor activity and low coagulation inhibitor levels promote thrombosis.
  • Thrombophilia is a significant risk factor for neonatal thrombosis, especially PAS.

Conclusions:

  • Neonates possess a unique, immature hemostatic system prone to thrombosis.
  • Understanding developmental hemostasis is crucial for managing neonatal thrombotic complications.
  • Further research and tailored treatment strategies are needed for pediatric thrombosis.