Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Isolation of Murine Peritoneal Macrophages to Carry Out Gene Expression Analysis Upon Toll-like Receptors Stimulation08:21

Isolation of Murine Peritoneal Macrophages to Carry Out Gene Expression Analysis Upon Toll-like Receptors Stimulation

38.0K
We describe here a simple protocol to isolate murine peritoneal macrophages. This procedure is followed by RNA extraction to carry out gene expression analysis upon Toll-like receptors...
38.0K
Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

5.5K
Here, a protocol for the measurement of the non-heme iron content in animal tissues is provided, using a simple, well-established colorimetric assay that can be easily implemented in most...
5.5K
Assessment of Leishmania Virulence within Cultured Macrophages04:46

Assessment of Leishmania Virulence within Cultured Macrophages

599
This video investigates Leishmania's virulence by treating macrophages with metacyclic promastigotes, resulting in the formation of intracellular amastigotes. The confirmation of Leishmania's virulence is achieved through nucleic acid fluorescent dye staining. This insight can contribute to the development of new therapies for...
599

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A recurrent ACAA2 variant causes a dominant syndrome of lipodystrophy, lipomatosis, infantile steatohepatitis, and hypoglycemia.

The Journal of clinical investigation·2025
Same author

Erratum. Gain of Function NOTCH3 Variants Cause Familial Partial Lipodystrophy Due to Activation of Senescence Pathways. Diabetes 2025;74:427-438.

Diabetes·2025
Same author

Minimally invasive radical surgery for gallbladder cancer: a single-unit experience of over 200 patients.

Surgical endoscopy·2025
Same author

A plain language summary of the LOCK IT-100 study of taurolidine/heparin catheter lock solution and catheter-related bloodstream infection in hemodialysis.

Future microbiology·2025
Same author

Ring enhancing lesion on CT scan: metastases or a brain abscess?

BMJ case reports·2025
Same author

Laparoscopic hepaticoduodenostomy for bilioenteric reconstruction: an experience.

Surgical endoscopy·2025
Same journal

The Physician Leader: Teaching Leadership in Medicine.

Advances in chronic kidney disease·2022
Same journal

Postgraduate Education and Training for the Nephrology Physician Assistants and Nurse Practitioners.

Advances in chronic kidney disease·2022
Same journal

Evaluation Evolution: Designing Optimal Evaluations to Enhance Learning in Nephrology Fellowship.

Advances in chronic kidney disease·2022
Same journal

Kidney Pathology Education for Nephrology Fellows: Past, Present, and Future.

Advances in chronic kidney disease·2022
Same journal

Clinician Educator Pathway for Nephrology Fellows: The University of North Carolina Experience.

Advances in chronic kidney disease·2022
Same journal

Current Trends and Challenges in Nephrology Fellowship Training: Expansion of Education in Home Dialysis, Palliative Care, and Point-of-Care Ultrasound.

Advances in chronic kidney disease·2022
See all related articles

Related Experiment Video

Updated: Jan 20, 2026

Isolation of Murine Peritoneal Macrophages to Carry Out Gene Expression Analysis Upon Toll-like Receptors Stimulation
08:21

Isolation of Murine Peritoneal Macrophages to Carry Out Gene Expression Analysis Upon Toll-like Receptors Stimulation

Published on: April 29, 2015

38.0K

Hepcidin.

Anil K Agarwal1, Jerry Yee2

  • 1The Ohio State University, Wexner Medical Center, Columbus, OH.

Advances in Chronic Kidney Disease
|September 4, 2019
PubMed
Summary
This summary is machine-generated.

Iron metabolism dysregulation causes anemia in chronic kidney disease (CKD). Hepcidin, a key iron regulator, offers new therapeutic targets for treating anemia of CKD.

Keywords:
AnemiaBMPFerroportinHepcidinIron

More Related Videos

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

5.5K
Assessment of Leishmania Virulence within Cultured Macrophages
04:46

Assessment of Leishmania Virulence within Cultured Macrophages

599

Related Experiment Videos

Last Updated: Jan 20, 2026

Isolation of Murine Peritoneal Macrophages to Carry Out Gene Expression Analysis Upon Toll-like Receptors Stimulation
08:21

Isolation of Murine Peritoneal Macrophages to Carry Out Gene Expression Analysis Upon Toll-like Receptors Stimulation

Published on: April 29, 2015

38.0K
Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

5.5K
Assessment of Leishmania Virulence within Cultured Macrophages
04:46

Assessment of Leishmania Virulence within Cultured Macrophages

599

Area of Science:

  • Nephrology
  • Hematology
  • Metabolic Disorders

Background:

  • Anemia is common in chronic kidney disease (CKD), often linked to iron metabolism issues.
  • Current markers for iron status are imperfect, leading to misdiagnosis and poor treatment outcomes for anemia.
  • Hepcidin, a liver-produced peptide, is a critical regulator of iron homeostasis.

Purpose of the Study:

  • To explore the role of hepcidin in the development and treatment of anemia of CKD.
  • To highlight the limitations of current iron status markers in CKD anemia.
  • To discuss the therapeutic potential of modulating hepcidin for anemia of CKD.

Main Methods:

  • Review of scientific literature on iron metabolism, hepcidin, and anemia of CKD.
  • Analysis of hepcidin's regulatory mechanisms (iron supply, erythropoiesis, inflammation).
  • Examination of the impact of altered hepcidin levels on iron status and erythropoiesis.

Main Results:

  • Hepcidin dysregulation is central to iron deficiency and overload in CKD anemia.
  • Hepcidin levels are influenced by iron availability, erythropoietic demand, and inflammation.
  • Altered hepcidin is linked to impaired red blood cell production and anemia.

Conclusions:

  • Understanding hepcidin's role provides crucial insights into hematologic disorders like CKD anemia.
  • Targeting hepcidin pathways with agonists or antagonists presents promising therapeutic strategies.
  • Development of hepcidin-modulating agents offers future treatment potential for anemia of CKD.