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Related Experiment Videos

Body mass and prostatic cancer: a prospective study.

R K Severson1, J S Grove, A M Nomura

  • 1Japan-Hawaii Cancer Study, Kuakini Medical Center, Honolulu 96817.

BMJ (Clinical Research Ed.)
|September 17, 1988
PubMed
Summary

Increased body mass may elevate prostate cancer risk, with lean muscle mass, not fat, potentially driving this association. Further research into tissue-specific mechanisms is needed for prostate cancer development.

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Area of Science:

  • Oncology
  • Epidemiology
  • Human Physiology

Background:

  • Previous research linked increased body mass to higher prostate cancer risk, but relied on limited measurements.
  • Studies often used simple metrics like height and weight, potentially obscuring nuanced relationships.

Purpose of the Study:

  • To investigate the association between detailed anthropometric measurements and prostate cancer risk.
  • To differentiate the roles of lean tissue versus fat tissue in the body mass-prostate cancer link.

Main Methods:

  • Prospective study of Japanese men (born 1900-19) in Hawaii.
  • Analysis of extensive anthropometric measurements, including arm muscle and fat areas.

Main Results:

  • Confirmed association between body mass and prostate cancer risk.
  • Found a significant positive association between arm muscle area and prostate cancer risk.
  • No significant association was observed between arm fat area and prostate cancer risk.

Conclusions:

  • Lean body mass, specifically muscle, may be more strongly associated with prostate cancer risk than fat mass.
  • Further investigation into the biological mechanisms of carcinogenesis involving lean and fat tissue is warranted.

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