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Updated: Jan 20, 2026

How to Obtain Reliable Visual Event-related Potentials in Newborns
Published on: October 24, 2019
Population-Based Newborn Screening for Mucopolysaccharidosis Type II in Illinois: The First Year Experience
Barbara K Burton1, George E Hoganson2, Julie Fleischer3
1Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL; Northwestern University Feinberg School of Medicine, Chicago, IL.
Objectives:
To assess the outcome of population-based newborn screening for mucopolysaccharidosis type II (MPS II) during the first year of screening in Illinois.
Study Design:
Tandem mass spectrometry was used to measure iduronate-2-sulfatase (I2S) activity in dried blood spot specimens obtained from 162 000 infant samples sent to the Newborn Screening Laboratory of the Illinois Department of Public Health in Chicago.
Results:
One case of MPS II and 14 infants with pseudodeficiency for I2S were identified.
Conclusions:
Newborn screening for MPS II by measurement of I2S enzyme activity was successfully integrated into the statewide newborn screening program in Illinois.
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