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Updated: Jan 20, 2026

Deep Brain Stimulation with Simultaneous fMRI in Rodents
Published on: February 15, 2014
Washout of chronic therapeutic deep brain stimulation increases cortical phase-amplitude coupling
Sheila S Rajagopalan1, Andrew M Miller2, Coralie de Hemptinne1
1Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Abstract:
Invasive human brain recordings have shown that acute therapeutic deep brain stimulation (DBS) reduces cortical synchronization, measured by coupling of beta phase to gamma amplitude. Here we show by noninvasive scalp electroencephalography that withdrawal of chronic DBS elevates phase-amplitude coupling, in proportion to the worsening of contralateral rigidity.
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