Real-time epileptic seizure prediction based on online monitoring of pre-ictal features

Reliable prediction of epileptic seizures is of prime importance as it can drastically change the quality of life for patients. This study aims to propose a real-time low computational approach for the prediction of epileptic seizures and to present an efficient hardware implementation of this approach for portable prediction systems. Three levels of feature extraction are performed to characterize the pre-ictal activities of the EEG signal. In the first-level, the line length algorithm is applied to the pre-ictal region. The features obtained in the first-level are mathematically integrated to extract the second-level features and then the line lengths of the second-level features are calculated to obtain our third-level feature. The third-level information is compared with predefined threshold levels to make a decision on whether the extracted characteristics are relevant to a seizure occurrence or not. The validity of this algorithm was tested by EEG recordings in the CHB-MIT database (97 seizures, 834.224 h) for 19 epileptic patients. The results showed that the average sensitivity was 90.62%, the specificity was 88.34%, the accuracy was 88.76% with the average false prediction rate as low as 0.0046 h^-1, and the average prediction time was 23.3 min. The low computational complexity is the superiority of the proposed approach, which provides a technologically simple but accurate way of predicting epileptic seizures and enables hardware implantable devices. Graphical abstract Proposed seizure prediction algorithm and its features.