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Related Experiment Videos

T3N0M0 glottic carcinoma--a failure analysis.

J A Lundgren1, R W Gilbert, A W van Nostrand

  • 1Department of Otolaryngoly, University of Toronto, Canada.

Clinical Otolaryngology and Allied Sciences
|December 1, 1988
PubMed
Summary

This study on T3N0M0 glottic carcinoma found primary radiotherapy yielded a 50.5% 5-year survival rate. Results varied by gender and age, with larynx preservation in 59% of survivors.

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Role of endolaryngeal surgery (with or without laser) compared with radiotherapy in the management of early (T1) glottic cancer: a clinical practice guideline.

Current oncology (Toronto, Ont.)·2013

Area of Science:

  • Otolaryngology
  • Oncology
  • Radiation Oncology

Background:

  • Management of T3N0M0 glottic carcinoma remains controversial.
  • This study evaluates outcomes for patients treated with primary radiotherapy.

Purpose of the Study:

  • To assess the efficacy of primary radiotherapy for T3N0M0 glottic carcinoma.
  • To identify factors influencing survival and local relapse rates.

Main Methods:

  • Retrospective analysis of 141 patients with T3N0M0 glottic carcinoma treated between 1964 and 1981.
  • Primary radiotherapy with surgery reserved for residual or recurrent disease.

Main Results:

  • 5-year actuarial survival was 50.5%; 28% died of glottic cancer.

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  • Local relapse-free rates were higher in females (68%) than males (41%) and older males (≥60 years) (46%) vs. younger males (<60 years) (31%).
  • Larynx preservation was achieved in 59% of 5-year survivors. High failure rates were associated with involvement of all laryngeal regions and initial tracheotomy.

    • Conclusions:

    • Primary radiotherapy offers a viable treatment option for T3N0M0 glottic carcinoma, with notable survival and larynx preservation rates.
    • Patient demographics and disease extent influence treatment outcomes, suggesting potential for tailored therapeutic strategies.
    • Further research is needed to optimize radiotherapy protocols for patients at high risk of treatment failure.