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Related Concept Videos

Observation and Analysis of Blinking Surface-enhanced Raman Scattering05:52

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This protocol describes the analysis of blinking surface-enhanced Raman scattering due to the random walk of a single molecule on a silver surface using power...
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The present protocol describes a convenient approach to integrating optical trapping and surface-enhanced Raman spectroscopy (SERS) to manipulate plasmonic nanoparticles for sensitive molecular detection. Without aggregating agents, the trapping laser assembles plasmonic nanoparticles to enhance the SERS signals of target analytes for in situ spectroscopic...
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Updated: Jan 20, 2026

Observation and Analysis of Blinking Surface-enhanced Raman Scattering
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Published on: January 11, 2018

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Present and Future of Surface-Enhanced Raman Scattering.

Judith Langer1, Dorleta Jimenez de Aberasturi1, Javier Aizpurua2

  • 1CIC biomaGUNE and CIBER-BBN , Paseo de Miramón 182 , Donostia-San Sebastián 20014 , Spain.

ACS Nano
|September 4, 2019
PubMed
Summary
This summary is machine-generated.

Surface-enhanced Raman scattering (SERS) offers ultrasensitive detection but requires further development for routine analytical and commercial use. This review summarizes SERS advancements and future prospects in sensing applications.

Keywords:
SEIRASERS tagsTERSbiosensingcatalysischarge transferchemosensorshot electronsnanomedicinesurface-enhanced Raman scattering

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Area of Science:

  • Spectroscopy
  • Analytical Chemistry
  • Materials Science

Background:

  • Surface-enhanced Raman scattering (SERS) is a technique that amplifies Raman signals from molecules on nanostructured metal surfaces.
  • It has been a significant development in spectroscopic and analytical techniques for 45 years.
  • SERS holds great potential for ultrasensitive sensing across diverse scientific fields.

Purpose of the Study:

  • To summarize the current state of understanding and application of SERS.
  • To highlight advancements in SERS research and technology.
  • To predict future trends in SERS research, applications, and development.

Main Methods:

  • Review of experimental and theoretical studies on the SERS effect.
  • Analysis of current SERS sensing applications.
  • Synthesis of expert perspectives on future SERS development.

Main Results:

  • SERS has matured into a rich research area with demonstrated ultrasensitive sensing capabilities.
  • Significant progress has been made in understanding the underlying mechanisms of SERS.
  • Challenges remain in achieving routine analytical and commercial deployment of SERS technology.

Conclusions:

  • Further research and development are necessary to overcome existing challenges for widespread SERS adoption.
  • The future of SERS involves continued exploration of its applications and technological refinement.
  • The review honors the foundational contributions of SERS pioneer Prof. Richard Van Duyne.