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Updated: Jan 20, 2026
Radical Substitution: Halogenation of Alkanes and Alkyl Substituents
Radical-Mediated Heck-Type Alkylation: Stereoconvergent Synthesis of Functionalized Polyenes
Hong Zhang1, Xinxin Wu1, Yunlong Wei1
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science , Soochow University , 199 Ren-Ai Road , Suzhou , Jiangsu 215123 , China.
Abstract:
The stereospecific synthesis of polyenes is of great synthetic value. Disclosed herein is a new, efficient, stereoconvergent approach for the synthesis of functionalized polyenes via a radical-mediated Heck-type alkylation. The easily accessed Z- and E-mixed alkenes are harnessed as starting material, leading to a unique stereoisomer of polyenes. In addition, the transformation features mild reaction conditions and broad functional group compatibility. A variety of valuable 1,3-dienes and 1,3,5-trienes are afforded in useful yields.
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