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Updated: Jan 20, 2026

An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis
Published on: November 22, 2024
A Strategy To Prepare Peptide Heterodimers in the Solid Phase with an Acid-Labile Linker
Gang Wang1, Tingting Chen1, Tao Peng1
1Beijing institute of Radiation Medicine , Beijing 100850 , P.R. China.
Abstract:
The currently synthetic methods of peptide heterodimer involve tedious synthesis and purification steps. An acid-labile traceless linker was prepared, which is highly compatible with the Fmoc strategy and could be used to prepare peptide heterodimer on resin. The linker could be cleaved concomitantly with peptide cleavage, and two model heterodimers were synthesized. The proposed synthesis procedure is simple, straightforward, and provides great convenience for preparing disulfide-linked peptide heterodimers.
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