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Updated: Jan 20, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
Published on: December 13, 2017
Dupuytren, Ledderhose, and Peyronie Diseases After Primidone Use For Essential Tremor
Luiz Felipe R Vasconcellos1, Daniel Nassif, Mariana Spitz
1Department of Neurology, Federal Hospital of Servidores do Estado, Rio de Janeiro-RJ, Brazil.
Introduction:
Dupuytren, Ledderhose, and Peyronie diseases are chronic fibrotic conditions related to progressive fibrosis of the palmar fascia, plantar fascia, and tunica albuginea, respectively. These conditions have been associated with antiepileptic drug use, mainly phenobarbital and primidone.
Case Report:
A 71-year-old man developed simultaneous Dupuytren, Ledderhose, and Peyronie diseases after primidone use for essential tremor.
Conclusions:
There are a few reports associating barbiturate use to connective tissue disorders, and some suggest that drug withdrawal may result in a better prognosis. Therefore, physicians must be aware of such adverse events when caring for patients on long-term barbiturate use.
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