Related Experiment Video
Updated: Jan 20, 2026
A Mouse Model for Laser-induced Choroidal Neovascularization
Published on: December 27, 2015
CHOROIDAL NEOVASCULARIZATION ASSOCIATED WITH LONG-CHAIN 3-HYDROXYACYL-CoA DEHYDROGENASE DEFICIENCY
Riccardo Sacconi1, Francesco Bandello, Giuseppe Querques
1Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy .
Purpose:
To report the first case describing choroidal neovascularization in long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency.
Methods:
Case report including multimodal imaging discussion.
Results:
A 21-year-old woman affected by LCHAD deficiency (confirmed by 1528 G>C homozygous mutation) was referred to our department for progressive visual decline in both eyes. Best-corrected visual acuities were 20/40 and 20/1,000 in the right and left eye, respectively. Ultra-widefield imaging, fluorescein angiography, structural optical coherence tomography, and optical coherence tomography angiography revealed the presence of macular and midperipheral chorioretinal atrophy complicated by a choroidal neovascularization in the left eye.
Conclusion:
Ocular changes in LCHAD deficiency are long-term complications and severely affect the quality of life of patients. We report for the first time the evidence that choroidal neovascularization could complicate ocular changes accelerating the progressive vision impairment.
Related Concept Videos
07:08A Mouse Model for Laser-induced Choroidal Neovascularization
09:56In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
06:10An Ex Vivo Choroid Sprouting Assay of Ocular Microvascular Angiogenesis
05:14Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography
06:57Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis
04:55A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse