Programmable Hierarchical Construction of Mixed/Multilayered Polysaccharide Nanocapsules through...

Area of Science:

• Materials Science
• Nanotechnology
• Polymer Chemistry

Background:

• Hierarchical capsular assemblies are crucial for various applications, including drug delivery.
• Existing methods for creating multicomponent nanocapsules often lack precise control over structure and composition.
• Developing simple, tunable methods for fabricating functional nanocarriers remains a significant challenge.

Purpose of the Study:

• To report a one-pot method for constructing oil-filled hierarchical capsular assemblies.
• To demonstrate precise control over nanocapsule dimensions, shell thickness, composition, and building block distribution.
• To explore the potential of this method for creating functional multilayered nanocarriers for biomedical use.

Main Methods:

• Utilized the nanoprecipitation technique for simultaneous and/or sequential precipitation of polymer combinations.
• Employed multicomponent phase diagrams to guide the programming of polymer self-assembly.
• Synthesized a library of neutral and ionic polysaccharides to create diverse nanocarrier structures.

Main Results:

• Successfully fabricated oil-filled hierarchical capsular assemblies with tunable multilayered structures.
• Achieved precise control over nanocapsule dimensions, shell thickness, and the spatial arrangement of components.
• Demonstrated the versatility of the approach using various polysaccharide combinations.

Conclusions:

• The reported one-pot nanoprecipitation method offers a simple and highly tunable approach for designing multicomponent nanocapsules.
• This technique provides precise control over nanocarrier architecture, enabling the creation of functional multilayered nanocarriers.
• The developed nanocarriers hold significant promise for diverse biomedical applications.