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Assessing Biofilm Dispersal in Murine Wounds

Assessing Biofilm Dispersal in Murine Wounds

Here, we describe ex vivo and in vivo methods for assessing bacterial dispersal from a wound infection in mice. This protocol can be utilized to test the efficacy of topical antimicrobial and anti-biofilm therapies, or to assess the dispersal capacity of different bacterial strains or species.

Swine Model of Biofilm Infection and Invisible Wounds

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Chronic wounds that are resistant to antibiotics are a major threat to the healthcare system. Biofilm infections are stubborn and hostile and can cause deficient functional wound closure. We report a clinically relevant swine model of biofilm-infected full-thickness chronic wounds. This model is powerful for mechanistic studies as well as for testing...

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Wounds represent a global health challenge. This study developed a standardized photo booth utilizing digital planimetry to minimize wound measurement variability. Monitoring wounds in mice over 14 days revealed an initial increase in wound area and perimeter, followed by gradual closure. This methodology may aid in evaluating wound closure kinetics in pre-clinical...

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Related Experiment Video

Updated: Jan 20, 2026

Assessing Biofilm Dispersal in Murine Wounds

Assessing Biofilm Dispersal in Murine Wounds

Published on: August 7, 2021

Wound assessment

Stephen Young¹

¹Managing Director, In Control Cambridge Ltd.

British Journal of Community Nursing

|September 4, 2019

Summary

No abstract available in PubMed .

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