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Published on: September 26, 2018
Apolipoprotein B/AI ratio as an independent risk factor for intracranial atherosclerotic stenosis
Yan Sun1, Xiao-He Hou1, Dong-Dong Wang1
1Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Insights
Higher apolipoprotein B/apolipoprotein AI (apoB/AI) ratios are linked to increased risk of intracranial atherosclerotic stenosis (ICAS). This finding holds true for both stroke patients and non-stroke individuals, highlighting apoB/AI as a key indicator.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Biomarkers
Background:
- Intracranial atherosclerotic stenosis (ICAS) is a significant cause of stroke.
- Apolipoprotein B/apolipoprotein AI (apoB/AI) ratio is a marker of atherogenic dyslipidemia.
- The association between apoB/AI ratio and ICAS risk in diverse populations requires further investigation.
Purpose of the Study:
- To examine the relationship between elevated apoB/AI ratio and the risk of developing ICAS.
- To assess this association in both acute ischemic stroke patients and a non-stroke control group.
Main Methods:
- A study cohort included 1138 acute ischemic stroke patients and 1072 non-stroke controls.
- ICAS was defined as >50% stenosis or occlusion of major intracranial arteries.
- Statistical analysis, including odds ratios (OR) and confidence intervals (CI), was used to determine risk.
Main Results:
- Patients with ICAS exhibited significantly higher apoB/AI ratios compared to those without ICAS, across both stroke and non-stroke groups.
- An elevated apoB/AI ratio was identified as an independent risk factor for ICAS in stroke patients (OR 2.80) and non-stroke individuals (OR 3.38).
- Higher quartiles of apoB/AI ratio demonstrated a dose-dependent increase in ICAS risk in both populations.
Conclusions:
- The apoB/AI ratio is a valuable and independent predictor of ICAS.
- This finding is consistent in both patients with a history of stroke and in individuals without stroke.
- Monitoring apoB/AI ratio may aid in identifying individuals at risk for ICAS.
Abstract:
To investigate the relation of higher apolipoprotein B/apolipoprotein AI (apoB/AI) ratio with the risk of suffering intracranial atherosclerotic stenosis (ICAS) in both stroke and non-stroke population, we enrolled 1138 patients with acute ischemic stroke (359 with ICAS, 779 without ICAS) and 1072 non-stroke controls (239 with ICAS, 833 without ICAS) into the study. ICAS was defined as atherosclerotic stenosis >50% or the occlusion of the several main intracranial arteries. ApoB/AI ratio of patients with ICAS was significantly higher than those of individuals without ICAS in both stroke group and non-stroke groups. Increased ratio of apoB/AI was an independent risk factor for ICAS in both stroke group (OR 2.80, 95% CI 1.45-5.42, p=0.002) and non-stroke groups (OR 3.38, 95% CI 1.61-7.12, p<0.001). Compared with the lowest quartile, the third (Stroke OR=1.71, 95%CI, 1.11-2.63, p=0.014; Non-stroke OR=1.71, 95%CI, 1.04-2.82, p=0.033) and forth quartiles (Stroke OR=2.06, 95%CI, 1.27-3.35, p=0.003; Non-stroke OR=2.00, 95%CI, 1.16-3.49, p=0.012) were independent risk factors for ICAS in both stroke (p value for trend=0.001)) and non-stroke (p value for trend=0.006) groups. In summary, increased apoB/AI ratio was a valuable independent risk factor for ICAS in stroke patients as well as in non-stroke controls.
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