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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease08:27

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Dynamic adhesion of immune cells to the vessel wall is a prerequisite for gut homing. Here, we present a protocol for a functional in vitro assay for the impact analysis of anti-integrin antibodies, chemokines or other factors on the dynamic cell adhesion of human cells using addressin-coated...
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DNBS/TNBS induced colitis offers an alternative and inexpensive method to study the pathobiology of inflammatory bowel disease. The protocol discussed in this paper outlines the successful application of DNBS to induce colitis in mice and rats and allows one to thoroughly study host-mediated intestinal...
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Related Experiment Video

Updated: Jan 20, 2026

Inflammatory Bowel Disease II: Crohn's Disease
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Performance measures in inflammatory bowel disease surveillance colonoscopy: Implementing changes to practice

Samuel C L Smith1, Rosanna Cannatelli1, Alina Bazarova1

  • 1Institute of Translational Medicine and Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society
|September 4, 2019
PubMed
Summary

Structured changes in service delivery significantly improved quality indicators for inflammatory bowel disease (IBD) surveillance using dye-based chromoendoscopy (DCE). This enhanced IBD surveillance practice led to increased DCE use and better lesion detection rates.

Keywords:
colonic lesion characterizationcolonic lesion detectiondye chromoendoscopykey performance quality indicatorsurveillance colonoscopy

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Area of Science:

  • Gastroenterology
  • Endoscopy
  • Inflammatory Bowel Disease (IBD) Management

Background:

  • Dye-based chromoendoscopy (DCE) with targeted biopsies is recommended for inflammatory bowel disease (IBD) surveillance.
  • Clinical adoption of DCE for IBD surveillance remains limited.
  • Structured changes in service delivery were implemented to evaluate quality indicators.

Purpose of the Study:

  • To evaluate the impact of structured changes in service delivery on quality indicators for IBD surveillance.
  • To assess the adoption and effectiveness of dye-based chromoendoscopy in clinical practice.

Main Methods:

  • Introduction of structured changes in IBD surveillance practice in August 2016.
  • Included interactive training, standardizing DCE with a pump jet, allocating 45-minute slots, targeted biopsies, disease activity scoring, and lesion characterization.
  • Comparison of quality measures pre- and post-August 2016 using chi-squared statistics.

Main Results:

  • DCE use increased from 54.2% to 76.0% (P < 0.0005), while random biopsy surveillance decreased.
  • Use of Paris classification and Kudo pit pattern significantly increased.
  • Lesion detection rate improved from 24.9% to 33.1% (P < 0.05).

Conclusions:

  • Implementation of practice changes significantly improved IBD surveillance quality indicators.
  • Training, education, and audit are key to facilitating DCE adoption.
  • Further improvements in IBD surveillance quality are achievable.