Related Experiment Video
Updated: Jan 20, 2026
Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
Published on: January 19, 2019
Core-shell-corona chitosan-based micelles for tumor intracellular pH-triggered drug delivery: Improving performance
1State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
Abstract:
Core-shell-corona chitosan-based micelles were designed for the tumor intracellular pH-triggered doxorubicin (DOX) delivery, via a facile in-situ micellization in an aqueous solution of DOX and polyethylene glycol (PEG) and poly(2-(diisopropylamino) ethyl methacrylate) (PDPA) dual-modified chitosan (PEG-g-CS-g-PDPA). The effect of the PDPA modification on the diameter, drug loading-capacity (DLC) and pH-triggered drug release was investigated for the three different polymerization degrees of PDPA (25, 32, and 42) with a similar modification degree of ~22%. The optimized ones, the core-shell-corona DOX/PEG-g-CS-g-PDPA32 micelles possessed a mean hydrodynamic diameter (Dh) of 211 nm and DLC of 54%, showing an excellent pH-triggered drug release with negligible premature drug leakage in 60 h. Such results indicated that grafting polycation could efficiently improve the performance of the chitosan-based drug delivery system (DDS) for tumor chemotherapy.
Related Concept Videos
08:30Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
09:56Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
11:05Capillary Electrophoresis to Monitor Peptide Grafting onto Chitosan Films in Real Time
08:44Assembly and Characterization of Polyelectrolyte Complex Micelles
07:14Enhanced Gene Delivery and Expression using Intraosseous Injection of Chitosan Nanoparticles Encapsulated Adenine Base Editor Plasmids
01:33Nanoparticle-Mediated Enhanced Delivery of an Anti-Inflammatory Drug in Microglia-Like Cells