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Related Concept Videos

The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy11:08

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Mice are widely used to study gestational biology. However, pregnancy termination is required for such studies which precludes longitudinal investigations and necessitates the use of large numbers of animals. Therefore, we describe a non-invasive technique of high-frequency ultrasonography for early detection and monitoring of post-implantation events in the pregnant mouse.
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Related Experiment Video

Updated: Jan 20, 2026

The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy
11:08

The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy

Published on: March 13, 2014

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Ursodeoxycholic acid in pregnancy?

Elsemieke de Vries1, Ulrich Beuers1

  • 1Department of Gastroenterology and Hepatology and Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, Location AMC, Amsterdam, The Netherlands.

Journal of Hepatology
|September 4, 2019
PubMed
Summary
This summary is machine-generated.

This case study examines ursodeoxycholic acid (UDCA) use in pregnancy for primary biliary cholangitis (PBC). It analyzes safety data to guide clinicians on UDCA prescription during pregnancy and lactation.

Keywords:
LactationPBCPSCPrimary biliary cholangitisPrimary sclerosing cholangitisStillbirthUDCA

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The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy
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Area of Science:

  • Hepatology
  • Maternal-Fetal Medicine
  • Pharmacology

Background:

  • Primary biliary cholangitis (PBC) is a chronic liver disease.
  • Management of PBC during pregnancy presents unique challenges due to drug safety concerns.

Observation:

  • A case of a 34-year-old woman with PBC before, during, and after pregnancy is presented.
  • The use of ursodeoxycholic acid (UDCA) during and after pregnancy was evaluated.

Findings:

  • Ursodeoxycholic acid (UDCA) lacks regulatory approval as a pregnancy-safe drug, leading to clinical hesitancy.
  • Analysis of current evidence, safety data, and clinical experience with UDCA and alternatives during pregnancy and lactation is provided.

Implications:

  • Provides evidence-based advice for clinicians on prescribing UDCA during pregnancy and lactation.
  • Aims to improve the management of primary biliary cholangitis in pregnant patients.
  • Highlights the need for further research on the safety of UDCA in pregnancy.