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Related Concept Videos

Enhanced Cochlear Coverage and Hearing Preservation in High-Frequency Hearing Loss via Electric Acoustic Stimulation with Longer Electrode03:49

Enhanced Cochlear Coverage and Hearing Preservation in High-Frequency Hearing Loss via Electric Acoustic Stimulation with Longer Electrode

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Electric acoustic stimulation (EAS) with longer electrodes can offer broader cochlear coverage and various types of maps in cases of high-frequency hearing loss. Combining less invasive surgery, flexible lateral-wall electrodes, and steroid administration permits deeper insertion with little or no surgical trauma, resulting in good preservation of...
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This article reports the development of a neuro-rehabilitation approach, "constraint-induced sound therapy (CIST)" for sudden sensorineural hearing loss. The aim of CIST is to prevent maladaptive cortical reorganization by using an enriched acoustic environment. CIST represents a safe, easy, inexpensive, and effective approach to treat sudden sensorineural hearing...
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Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage07:13

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Here, we present a protocol for a mouse model of noise-induced hearing loss (NIHL). To induce NIHL, we developed a new and simple device using corrugated plastic, a rat trap cage, and a speaker. Auditory brainstem response and immunofluorescence imaging were employed to assess the hearing function and outer hair cell damage,...
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Inducing Hearing Loss in Mice Through Prolonged High-Volume Sound Exposure01:52

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Source: Lee, D. et. al., Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage. J. Vis. Exp. (2023)This video demonstrates the procedure of noise-induced hearing loss in mice. High-volume sound damages hair cells in the inner ear and disrupts auditory pathways, resulting in hearing...
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Simple Surgical Induction of Conductive Hearing Loss with Verification Using Otoscope Visualization and Behavioral Clap Startle Response in Rat06:27

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Miniature pigs (mini-pigs) are an ideal large animal model for research into cochlear implants. Cochlear implantation surgery in mini-pigs can be utilized to provide initial evidence of the safety and potential performance of novel electrode arrays and surgical approaches in a living system similar to human...
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Related Experiment Video

Updated: Jan 20, 2026

Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation
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Current small animal models for LASV hearing loss.

Rachel A Sattler1, Junki Maruyama1, Nathan Y Shehu2

  • 1Department of Pathology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, 77551-0609, USA.

Current Opinion in Virology
|September 4, 2019
PubMed
Summary
This summary is machine-generated.

Lassa virus (LASV) causes severe illness and hearing loss in West Africa. This review examines the only small animal model for LASV-induced hearing loss, highlighting the need for new treatments.

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Last Updated: Jan 20, 2026

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Area of Science:

  • Virology
  • Infectious Diseases
  • Otolaryngology

Background:

  • Lassa virus (LASV) is a significant public health concern in West Africa, causing hundreds of thousands of infections and thousands of deaths annually.
  • High mortality rates and severe long-term sequelae, particularly sensorineural hearing loss (SNHL), underscore the urgent need for effective interventions.
  • Current therapeutic options for LASV infection are extremely limited, and the mechanisms underlying LASV-induced SNHL are poorly understood.

Purpose of the Study:

  • To review the existing small animal model for studying Lassa virus-induced hearing loss.
  • To identify potential surrogate models for investigating LASV pathogenesis and evaluating therapeutic strategies for hearing loss.

Main Methods:

  • Literature review of studies investigating Lassa virus infection and its effects on hearing.
  • Analysis of the characteristics and limitations of the currently available small animal model for LASV-induced hearing loss.
  • Exploration of potential alternative animal models that could serve as surrogates for studying LASV and its ototoxic effects.

Main Results:

  • The review identifies a specific small animal model as the sole existing resource for studying LASV-induced hearing loss.
  • The current model's utility and limitations in recapitulating human disease manifestations are discussed.
  • Several potential surrogate models are proposed for further research into LASV pathogenesis and therapeutic development for hearing loss.

Conclusions:

  • There is a critical need to understand the mechanisms of Lassa virus-induced hearing loss and to develop effective treatments.
  • The identified small animal model provides a crucial platform for this research, despite its limitations.
  • Further investigation using this model and potential surrogate models is essential for advancing therapeutic strategies against LASV-induced sequelae.